期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PTEN、FHIT基因在胃腺癌中的表达及其意义 被引量：3

Expression and significance of PTEN and FHIT in gastric carcinoma
暂未订购
导出
摘要 目的:探讨PTEN和FHIT基因在胃腺癌中的表达及其临床意义。方法:采用免疫组织化学(Envi-sion二步法)检测56例胃腺癌组织及10例正常胃黏膜组织中PTEN和FHIT基因蛋白的表达。结果:56例胃腺癌组织中PTEN和FHIT蛋白阳性表达率分别为41.1%和46.4%,正常胃黏膜组织均为100%,差异均有统计学意义(P<0.05)。PTEN蛋白的表达与胃腺癌的分化程度、浆膜浸润、淋巴结转移均有关(P<0.05)。FHIT蛋白的表达与胃腺癌淋巴结转移、浆膜浸润无关(P>0.05),与胃腺癌的分化程度有关(P<0.05)。结论:PTEN和FHIT基因蛋白缺失在胃腺癌发生、发展中起重要作用,二者可作为判断胃腺癌生物学行为和临床预后的参考指标。 Objective： To investigate the expression of PTEN and FHIT in gastric carcinoma and their clinical significance Methods： The expression of PTEN and FHIT in 56 cases of gastric carcinoma and their normal tissues were detected by Envision. Results： The positive rate of expression of PTEN and FHIT in 56 gastric carcinoma tissue were 41. 1% and 46.4% respectively, the paracancerous tissues showed all positive 100% ; the differences were statistically significant （P 〈0.05）. PTEN expression was correlated with the differentiation, range of invasion, lymph node metastasis （P 〈0.05）. FHIT expression had no correlation with, range of tumor in invasion, lymph node metastasis （P 〉0.05）, but was related with the degree of differentiation （P 〈0.05）. Conclusion： Decrease or absence expression of PTEN and FHIT protein play an important role in the genesis and development of gastric carcinoma; the two proteins can be used to judge carcinomatous biological behaviors and prognosis.
作者 徐国义 刘存
机构地区 新疆医科大学基础医学院病理解剖学教研室
出处 《新疆医科大学学报》 CAS 2008年第4期421-423,共3页 Journal of Xinjiang Medical University
关键词 胃腺癌 PTEN基因 FHIT基因 gastric carcinoma PTEN gene FHIT gene
分类号 R734.202 [医药卫生—肿瘤] R735.1 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidale tumor suppressor gene, MMACl, al chromosome 10q23.3 that is mutaled in multiple advanced cancers[J]. Nat Genet, 1997,15(4):356-362.
  • 2Ohta M, Inoue H, Cootdcelli MG, et al. The FHIT gene, spanning the chromosome 3q14.2 fragile site and renal carcinoma associated t(3 ;8) breakpoint , is abnormal in digestive tract cancers[J]. Cell, 1996,84:587.
  • 3Bose S, Wang SI, Terry MB, et al. Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas[J]. Oncogene, 1998,17 : 123.
  • 4Stambolic V, Suzuki A, Pompa JL, et al. Negative Regulation of PKB/Akt dependent cell survival by the tumor suppressor PTEN[J]. Cell,1998, 95:29.
  • 5Feilotler HE, Coulon V, McVeigh JL, et al. Analysis of the 10q23 chromosomal region and the PTEN gene in human breast carcinoma[J]. Br J Cancer, 1999,79(5-6) :126.
  • 6Wang YE, Wu X, Suzuki H, et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression [J]. Proc Natl Acad Sci USA, 1998, 95:5246.
  • 7Sozzi G, Veronese ML, Negrini M, et al. The FHIT gene at 3P14.2 is abnormal in lung cancer[J]. Cell,1996,85:17-26.
  • 8Druck T, Hadaczek P, Ohta M, et al. Structure and expression of the human FHIT gene in normal and tumor cells[J]. Cancer Res ,1997,57:504-512.
  • 9Tanaka H, Shimada Y, Harada H, et al. Methylation of the 5'CpG is land of the FHIT gene is closely associated with transcription in activation in esophageal squamous cell carcinomas [J]. Cancer Res, 1998,58 : 3429-3434.
  • 10Siprashvili Z, Sozzi G, Barnes L, et al. Replacement of FHIT in cancer cells suppresses tumorigenicity [J]. Proc Natl Acad Sci USA, 1997,94:13771-13776.

二级参考文献20

  • 1Ohta M, Inoue H, Cotticelli MG, et al. The FHIT genespanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) break-point, is abnormal in digestive tract cancers[J]. Cell, 1996,84(4):587-597.
  • 2Kawaguchi K, Yashima K, Koda M, et al. Fhit expression in human gastric adenomas and intramucosal carcinomas:correlation with Mlh1 expression and gastric phenotype [J]. Br J Cancer, 2004,90(3):672-677.
  • 3Zlotorynski E, Rahat A, Skaug J, et al. Molecular Basis for Expression of Common and Rare Fragile Sites [J].Molecular and Cellular Biology, 2003,23(20):7143-7151.
  • 4Hao XP, Willis JE, Pretlow TG, et al. Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions[J]. Cancer Res, 2000,60(1):18-21.
  • 5Huang K, Arabshahi A, Wei Y, et al. The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96GFhit[J]. Biochemistry, 2004,43(23):7637-7642.
  • 6Krummel KA, Denison SR, Calhoun E, et al. The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fre8E1 [J]. Genes Chromosomes Cancer, 2002,34(2):154-167.
  • 7Rocco A, Schandl L, Chen J, et al. Loss of FHIT protein expression correlates with disease progression and poor differentiation in gastric cancer [J]. J Cancer Res Clin Oncol, 2003,129(2):84-88.
  • 8Guler G, Uner A, Guler N, et al. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma[J]. Cancer, 2004,100(8):1605-1614.
  • 9Kannangai R, Sahin F, Adegbola O, et al. FHIT mRNA and protein expression in hepatocelluar carcinoma [J].Mod Pathol, 2004,17(6):653-659.
  • 10Toledo G, Sola JJ, Lozano MD, et al. Loss of FHIT protein expression is related to high proliferation, low apoptosis and worse prognosis in non-small-cell lung cancer [J]. Mod Pathol, 2004,17(4):440-448.

同被引文献22

引证文献3

二级引证文献5

新疆医科大学学报
2008年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部