摘要
目的：比较丙谷胺与熊去氧胆酸治疗胆囊结石的疗效。方法：将１６０例胆囊结石病人随机分为２组。丙谷胺组８０例（男性１２例，女性６８例；年龄３８±ｓ５ａ），用丙谷胺片每次５片（０．２ｇ／片），ｐｏｂｉｄ。熊去氧胆酸组８０例（男性１１例，女性６９例；年龄３７±６ａ），用熊去氧胆酸片４片（５０ｍｇ／片），ｐｏ，ｔｉｄ。２组病例均加用硝苯地平片每次１片（１０ｍｇ／片），ｐｏ，ｔｉｄ；３３％硫酸镁溶液２０ｍＬ，ｑｎ。２组疗程均为３ｍｏ。结果：丙谷胺组总有效率６０％，治愈率３０％，熊去氧胆酸组总有效率３９％和治愈率１２％（Ｐ＜０．０１）。结论：丙谷胺的疗效优于熊去氧胆酸。
AIM: To compare the therapeutic effects between proglumide and ursodeoxycholic acid in treatment of cholecystolithiasis. METHODS: The 160 patients with cholecystolithiasis were randomly divided into 2 groups. The 80 patients received proglumide 1 g po bid for 3 mo. Another 80 patients received ursodeoxycholic acid 0.2 g po tid for 3 mo. All patients were treated with nifedipine and magnesium sulfate too. RESULTS: Total effective rates were 60% for proglumide and 39% for ursodeoxycholic acid; cure rates were 30% for proglumide and 12% for ursodeoxycholic acid (P<0.01). CONCLUSION: Proglumide is more effective than ursodeoxycholic acid.
出处
《新药与临床》
CSCD
北大核心
1997年第6期341-342,共2页
关键词
胆结石
丙谷胺
熊去氧胆酸
药物疗法
cholelithiasis
proglumide
ursodeoxycholic acid
nifedipine
magnesium sulfate
