摘要
目的了解近3年重庆市耐药结核病流行现状,为耐药结核病的预防、控制提供依据。方法收集2003年6月至2006年6月间在重庆市结核病防治所及重庆市胸科医院就诊的肺结核病病例,按照《全国结核病诊断细菌学检验规程》,采用比例法对链霉素(Streptomycin,SM)、异烟肼(Isoniazide,INH)、利福平(Rifampicin,RFP)和乙胺丁醇(Ethambu-tol,EMB)共4种药物进行耐药性测定。结果1 089例痰培养阳性肺结核病例中,总耐药率和总耐多药率分别为27.7%、7.3%,平均耐药率顺位由高到低是SM(16.3%)、INH(14.0%)、RFP(10.7%)、EMB(4.8%);近3年RFP、EMB的耐药率和耐多药率呈逐年上升趋势。结论重庆市总体耐药水平接近全国平均水平,且近年耐多药率和RFP、EMB的耐药率呈上升趋势,复治、有服药史以及人均年可支配收入低于平均水平可能是结核病病例发生多耐药的相关因素。
Objective To explore the prevalence of drug-resistant tuberculosis in the past 3 years in Chongqing. and found basis for prevention, control and treatment drug-resistant tuberculosis. Methods Cases diagnosed as pulmonary tuberculosis were collected from Chongqing Chest Hospital and Institute of Tuberculosis Prevention and Treatment of Chongqing from June 2003 to June 2006. Proportion method was used to test the drug susceptibility of isoniazide （INH）, rifampicin （RFP）, streptomycin （SM） and ethambutol （EMB）. Results All 1 089 cases with positive sputum culture were subjected. The total frequency of drug resistance and multi-drug resistance were respectively 27.7% and 7.3%. The drug-resistance rate of SM, INH, RFP and EMB were respectively 16.3% , 14.0% , 10.7% and 4.8%. The drug resistance and multi-drug resistance to RFP and EMB were increased gradually. The factors including retreatment, drug history, and lower annual disposable income per capita may promote the occurrence of multi-drug resistant tuberculosis. Conclusion The frequency of drug resistance to tuberculosis in Chongqing is close to the average of whole nation, and, multi-drug resistant rate and the RFP and EMB resistance rates are increasing in recent years. We need to establish and strengthen the continal monitoring on drug resistant tuberculosis in order to prevent and control it.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2008年第12期1183-1185,共3页
Journal of Third Military Medical University
基金
国家自然科学基金(30700685)~~
关键词
耐药
结核病
相关因素
drug resistance
tuberculosis
relate factors
