摘要
目的:探讨二甲双胍联用银杏叶片治疗老年人代谢综合征(MS)的疗效。方法:老年代谢综合征患者68例随机分成2组,分别予二甲双胍,二甲双胍+银杏叶片口服1年,观察腰围(WC)、糖化血红蛋白(HbA1C)、空腹血糖(FPG)、餐后2h血糖(2hPG)、收缩压(SBP)、舒张压(DBP)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)指标。结果:二甲双胍组在治疗前后显示WC、HbA1C、FPG、2hPG均有下降(P<0.05),二甲双胍+银杏叶片组在治疗前后显示WC、HbA1C、FPG、2hPG、SBP、DBP、LDL-C、TG均有下降(P<0.05),HDL-C均有上升(P<0.05),两组比较差异有统计学意义(P<0.05);二甲双胍+银杏叶片组各项指标达标率与二甲双胍组比较均有增高。结论:二甲双胍+银杏叶片对老年人代谢综合征患者血管病变的防治起到积极作用。
Objective： To explore the efficacy of metformin coupled with extract of Ginkgo biloba for treatment of metabolism syndrome in the elderly. Methods： 68 patients suffered from metabolim syndrome were allocated into 2 groups at random. They received oral metfromin （contro group, n--33） and mefformin coupled with extract of Ginkgo biloba （treatment group, n=35） for 6 months, respectively. For all of them, WC,HbA1c,FPG,2hPG, SBP, DBP, LDL-C,TG, HDL-C were meaured. Results： In control group, there were significant decreases in WC, HbA1c, FPG and 2hPG after treatment compared to those before treatment （P〈 0.05）. In treatment group, the values of WC, HbA1c, FPG, 2hPG, SBP, DBP, LDL-C and TG after treatment were significantly lower than those before treatment （P〈0.05）, while HDL-C was elevated as contrary （P〈 0.05）. There were significant differences between control group and treatment group.For all of measurement, standard-reaching ratios in treatment group were raised compared to control group （P〈0.05）. Conclusion： Metformin coupled with extract of Ginkgo biloba has clinical effects in the patients with metabolism syndrome.
出处
《天津医科大学学报》
2008年第2期232-234,共3页
Journal of Tianjin Medical University
关键词
二甲双胍
银杏叶片
代谢综合征
Metformin
Extract of Ginkgo biloba（EGB）
Metabolic syndrome
