摘要
目的:观察扶正固本为主联合化疗治疗晚期非小细胞肺癌(NSCLC)的临床疗效。方法:189例晚期NSCLC住院患者随机平均分为中西药组(化疗加口服扶正固本为主中药治疗)63例、中药组(单纯口服扶正固本为主中药治疗)63例和单纯化疗组63例,治疗期为3个月,并比较3组进行临床疗效、生存质量、不良反应和体重等。结果:中西药组、中药组、单纯化疗组近期有效率(CR+PR)分别为17.5%、3.1%和7.8%,中西药组疗效优于中药组和单纯化疗组(P<0.05),且中西药组、中药组患者在临床症状变化、生活质量方面均优于单纯化疗组(P<0.05);治疗后体重均有下降,中西药组、中药组下降低于单纯化疗组(P<0.05);中西药组的化疗毒性发生率及毒性程度均较单纯化疗组明显减轻(P<0.05)。结论:扶正固本为主联合化疗治疗NSCLC具有较好作用,能提高患者的生活质量、近期有效率、体重,具有减毒增效作用。
Objective：To observe the therapeutic effect of the Fu Zheng Gu Ben （FZGB） with chemotherapy （CT） in treating advanced stage non-small cell lung cancer（NSCLC）. Methods： One hundred and eighty-nine NSCLC patients were randomly divided into the integrated traditional and western medicine （ITWM） group （ITWM group,63 patients treated with CT plus FZGB）, the Chinese medicine （CM）treated group （CM group, 63 patients treated with FZGB alone） and the chemotherap alone group（ACT） （ACT group,63 patients treated with CT alone）. The clinical effect ,quality of life （Qol） ,adverse reaction and body weight in the three groups were observed. Results： The immediate effective rates （ CR ＋ PR） in the ITWM group, CM group and ACT group was 17.5% ,3.1% and 7.8% ,respetively, in the ITWM group , it was better than that in other two groups （ P 〈 0.05 ）. The improvement of clinical symptoms and QOL in the ITWM and CM group were superior to those in the 3 groups. The reduction in the ITWM and CM group was lower than that in ACT group （ P 〈 0.05 ）. Moreover, the incidence rate and degree of toxicity were milder in the ITWN group than those in the ACT group （P 〈 0.05 ）. Conclusion ： The FZGB with CT has definite effect in treating NACLC, it could raise the QOL, the immediate effective rate the body weight ,also reduce the toxicity.
出处
《现代肿瘤医学》
CAS
2008年第6期981-983,共3页
Journal of Modern Oncology
关键词
中西医结合治疗
非小细胞肺癌
生活质量
不良反应
integrated traditional Chinese and western medicinal therapy
non -small cell lung cancer
quality of life
adverse reaction
