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支气管扩张患者病原菌的分布及耐药性分析 被引量:14

Analysis of bacterial distribution and drug resistance in patients with bronchiectasis
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摘要 目的分析支气管扩张患者病原菌的分布及耐药情况。方法对我院2004—2007年住院的106例支气管扩张患者进行痰一般致病菌培养及药物敏感分析。结果106例患者病原菌检出阳性48例(45.2%),共分离出细菌49株,铜绿假单胞菌33株(67.4%),鲍曼不动杆菌8株(16.3%),肺炎克雷伯杆菌4株(8.3%),斯氏假单胞菌1株(2%),洛菲不动杆菌1株(2.0%),大肠埃希氏菌1株(2.0%),白色念珠菌1株(2.0%)。结论支气管扩张患者病原菌铜绿假单胞菌排在首位,提示合理选用抗菌药物对减少耐药菌的产生有重要作用。 Objective To analyze the bacterial distribution and drug resistance in patients with bronchiectasis. Methods Sputum bacterial cultivation and drug sensitivity tests were performed on 106 bronchiectasis patients from 2004 to 2007. Results There were 48 positive cases among 106 bronchiectasis patients (45.2%) by sputum bacterial cultivation. Forty-nine strains of bacteria were isolated including 33 cases of Pseudomonas aeruginosa (67.4 % ), 8 cases of Baumanii ( 16.3 % ), 4 cases of Klebsiella pneumoniae ( 8.3 % ), 1 case of Pseudomonas stanieri (2.0%), 1 case of Acinetinbacter lwoffi (2.0%), 1 case of Escherichia coli. (2.0%) and 1 case of Candida albicans (2.0%). Conclusion Pseudomonas aeruginosa were is isolated most frequently in patients with bronchiectasis. It is suggested that reasonable use of antibiotics to reduce drug resistance is very important.
出处 《同济大学学报(医学版)》 CAS 2008年第3期50-53,共4页 Journal of Tongji University(Medical Science)
关键词 支气管扩张 细菌培养 药物敏感试验 bronchiectasis bacterial culture drug sensitivity test
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  • 1Pasteur MC, Helliwell SM, Houghton S J, et al. An investigation into causative factors in patients with bronchiectasis[ J]. Am J Respir Crh Care Med,2000, 162(4 Pt 1 ) : 1277 - 1284.
  • 2Angrill J,Agusti C, De Celis R,et al. Bacterial colonisation in patients with bronehiectasis:microbiological pattern and risk factors[ J]. Thorax,2002,57( 1 ) :15 - 19.
  • 3Maglio D, Kuti JL, Nicolau pharmacodynamic exposure DP. Simulation of antibiotic for the empiric treatment of nosocomial bloodstream infections: a report from the OPTAMA program [ J ]. Clin Ther, 2005,27 ( 7 ) : 1032 - 1042.
  • 4Scheinberg P,Shore E. A pilot study of the safety and ettlcacy of tobramycin solution for inhalation in patients with severe bronchiectasis [ J ]. Chest,2(D5,127:142 - 146.

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