摘要
目的:观察二氧化碳(CO2)超临界提取的丹皮酚的抗炎作用。方法:用醋酸导致小鼠腹腔毛细血管通透性增加;用角叉菜胶导致大鼠足跖肿胀。结果:丹皮酚50.0、25.0、12.5 mg/kg灌胃给药,可明显降低小鼠腹腔毛细血管通透性;丹皮酚32.0、16.0、8.0mg/kg灌胃给药,能显著抑制角叉菜胶所引起的大鼠足肿胀。结论:经CO2超临界提取的丹皮酚具有明显的抗炎作用。
Objective：To observe the anti-inflammatory effects of paeonol obtained through supercritical CO2 fluid extraction. Methods ： Anti - inflammatory effect of paeonol was observed by examining the permeability increase of mouse abdominal capillary induced by acetic acid and carrageenin - induced paw edema. Results： Gastric perfusion of paeonol at the dose of 50. 0mg/kg, 25.0mg/kg and 12.5mg/kg could markedly inhibit acetic acid-triggered increase of abdominal capillary permeability; Gastric perfusion of paeonol at the dose of 32.0mg/kg, 16. 0mg/kg and 8.0mg/kg could significantly inhibit paw edema induced by carrageenin. Conclusion： Paeonol obtained through supercritical CO2 fluid extraction definitely exerts anti -inflammatory effects.
出处
《包头医学院学报》
CAS
2008年第3期238-239,共2页
Journal of Baotou Medical College
关键词
丹皮酚
二氧化碳
超临界提取
抗炎
Paeonol
Supercritical CO2
Fluid extraction
Anti - inflammatory
