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多囊卵巢综合征代谢特点及治疗观察

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摘要 目的观察多囊卵巢综合征(PCOS)代谢特征及不同治疗的疗效。方法对77例患者按体质指数(BMI)分为肥胖型和非肥胖型,分别进行体检,测定性激素和糖脂代谢情况;按治疗方法不同分2组,A组(38例)单用二甲双胍,B组(39例)给予二甲双胍+氟他胺治疗3月,观察治疗前后人体学测量、性激素及糖脂代谢变化。结果(1)肥胖型与非肥胖型比较腰臀比(WHR)、收缩压、舒张压、OGTFl20min血糖、0min及120min胰岛素、胰岛素抵抗指数(HOMA.IR)、HDL、黄体生成素(LH)、LH/卵泡刺激素(FSH)差异有统计学意义(P〈0.05,P〈0.01)。(2)治疗3个月以后,2组治疗前后BMI、LH/FSH、总睾酮(TT)、TG、HDL、LDL、HOMA-IR水平变化差异均有统计学意义,但B组治疗前与治疗后差异有统计学意义(P〈0、05,P〈0.01)。结论肥胖型PCOS存在更严重的内分泌代谢紊乱;二甲双胍能改善这种紊乱,加用氟他胺更利于多毛症的改善。
出处 《中国医师杂志》 CAS 2008年第5期629-631,共3页 Journal of Chinese Physician
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