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莫达非尼对大鼠海马神经元IGABA的抑制作用机制

Pharmacological properties of modafinil in rat hippocampus pyramidal neurons
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摘要 目的研究新型促醒药莫达非尼对培养的大鼠海马神经元GABAA受体介导的电流(IGABA)的影响。方法在培养的海马锥体神经元上,进行全细胞膜片钳记录。结果GABA引起电流能被GABAA受体的竞争性阻断剂荷包牡丹碱阻断。单独给予莫达非尼时,明显地抑制了内向电流IGABA。而格列本脲预处理海马神经元后,再单独给予莫达非尼,发现莫达非尼对于IGABA的抑制作用被逆转。结论新型促醒药莫达非尼不同于传统的兴奋剂,莫达非尼对于神经元的保护作用可能与ATP敏感性钾离子通道的开放有关。 Aim To study the effects of a novel psychoactive drug, modafinil, on the GABAA receptor-induced current in rat hippocampus pyramidal neurons. Methods Whole-cell patch-clamp recordings were applied in cultured hippocampus pyramidal neurons. Results The GABA-activated currents were blocked by bicuculline, a competitive antagonist of GABAA receptor. Modafinil could partly inhibit IGABA Pre-treating hippocampus neurons with glibenclamide for 30 min, modafinil-induced inhibition on IGABA was removed. Conclusion Modafinil is different from other psychostimulants. The protection of modafinil may be via modulating ATP sensitive potassium channel activa- tion.
作者 王元银 黄擎 唐慧 王烈成
机构地区 安徽医科大学口腔医学院 安徽医科大学基础医学院
出处 《中国药理学通报》 CAS CSCD 北大核心 2008年第6期727-730,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30670694) 安徽省教育厅自然科学研究基金资助项目(NoNSFA2006KJ361B)
关键词 莫达非尼 GABA ATP敏感性钾离子通道 海马神经元 膜片钳 modafinil GABA ATP-sensitive potassi-um channel hippocampus patch clamp
分类号 R-332 [医药卫生] R338 [医药卫生—人体生理学]
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参考文献16

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中国药理学通报
2008年 第6期

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