摘要
目的:了解呼吸道感染患者肠杆菌科细菌产超广谱β-内酰胺酶(ESBLs)菌株的检出率及对常用抗生素的耐药情况。方法:收集呼吸道感染患者痰标本中分离出的肠杆菌科细菌326株,用标准纸片扩散法检测ESBLs,用K-B琼脂扩散法做药敏试验。结果:326株肠杆菌科细菌中,共检出产ESBLs菌109株,检出率为33.4%,其中肺炎克雷伯菌63株(37.1%),大肠埃希菌36株(35.6%)。除亚胺培南外,产ESBLs菌对其他常用抗生素的耐药率显著高于非产ESBLs菌。亚胺培南对ESBLs全部敏感,头孢哌酮/舒巴坦耐药率较低,其余抗生素耐药率均较高。结论:呼吸道感染患者痰中肠杆菌科细菌产ESBLs情况严重,临床实验室有必要常规检测ESBLs。亚胺培南是治疗产ESBLs菌感染的有效抗生素。
Objective： To detect production of enterobacteriaceae producing extended spectrum β-lacta-mases （ESBLs） in respiratory tract infection and drug - resistance to 10 kinds of antibacterial drugs. Method. Disc confirmatory test was used to detect ESBLs in 326 strains of enterobacteriaceae ; Kirby-Bauer agar diffusion method was used to judge drug sensitivity. Result： In this sample , productive rate of ESBLs was 33.4%, and productive rate of ESBLs in Klebsiella pneumonia and escherichia coli was 37.1% and 35. 6%. The ESBLs-producing strains had very high drag - resistance rate for the all antibiotics except for imipenem . The resistant rates of cefoperazone/sulbactam to ESBLs - Producing strains were the lower. Conclusion： The prevalence of ESBLs in isolates of enterobacteriaceae in respiratory tract infection ; it is necessary for clinical laboratory to detect ESBLs in isolates of enterobacteriaceae routinely. Imipenem was the effective antibiotics to infections caused by ESBLs-producing strains .
出处
《河北医学》
CAS
2008年第6期670-672,共3页
Hebei Medicine
关键词
呼吸道感染
肠杆菌科
超广谱Β-内酰胺酶
耐药性
Respiratory tract infection
Enterobacteriaceae
Extendedspectrum β-lactamases
Antibiotic resistance
