摘要
目的与人血白蛋白造影剂(全氟显)对比研究,评价脂质超声造影剂的心肌显影效果。方法不同程度单只冠脉(前降支和回旋支)狭窄实验犬10只,随机先后经静脉持续输注两种造影剂,定性和定量分析心肌血流灌注的情况以及血压和心率的变化,并检测超声造影剂的大小和浓度。结果脂质超声造影剂的浓度和大小[分别为(1.06±0.22)×109个/ml和(3.04±0.34)μm]与白蛋白超声造影剂[分别为(1.31±0.33)×109个/ml和(2.88±0.58)μm]相近(P>0.05)。两种造影剂的心肌显影均为3级,但对心率和血压均无明显影响(P>0.05)。定量分析显示:两种造影剂获得的正常冠脉区和狭窄冠脉区心肌血流容积(A)、血流速度(β)和血流量(A·β)均无显著差异(P>0.05),并且两种造影剂各参数间均呈显著性相关(P<0.05,rA=0.809,rβ=0.932,rA·β=0.925)。结论自制的脂质超声造影剂具有与全氟显相同良好的心肌显影效果,可用于定量评价心肌灌注显影。
Objective To evaluate the effect of a phospholipid-coated microbubble contrast agent for myocardium opacification in comparison with a albumin-coated microbubble contrast agent （Quanfuxian）. Methods In 10 dogs with single coronary artery stenosis involving the anterior descending branch or circumflex branch randomly received infusion of the two contrast agents through the femoral vein. The myocardial blood flow, heart rate and blood pressure were analyzed qualitatively and quantitatively. The concentration and the particle diameter of the two contrast agents were determined. Results The concentration of the phospholipid-coated microbubbles was （1.06±0.22）×10^9/ml, with a diameter of 3.04±0.34 μm, similar to the Concentration and diameter of Quanfuxian [（1.31 ±0.33）×10^9/ml and 2.88±0.58 μm, respectively, P〉0.05 ]. Both of the agents achieved grade three myocardium opacification, and produced no obvious effect on the heart rate and blood pressure. Quantitative analysis of myocardial opaciflcation in terms of myocardial blood volume （A）, blood velocity （β）, and blood flow （A×β） revealed no significant difference between the two agents （P〉0.05）, and the parameters derived from the two agents showed good correlations （P〈0.05, rA=0.809, rβ=0.932, rA-β=0.925）. Conclusion The phospholipid-coated microbubble contrast agent shows good effect for myocardial opacification without significant difference from Quanfuxian. Both of the agents are good ultrasound contrast agents for quantitative analysis of myocardium blood flow.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第5期684-686,691,共4页
Journal of Southern Medical University
基金
国家"863"科技计划项目(2006AA02Z478)~~
关键词
超声造影剂
心肌声学造影
脂质
白蛋白
ultrasound contrast agent
myocardial contrast echocardiography
lipid
albumin
