摘要
目的:探讨肺癌患者肿瘤标记物在早期诊断方法中采用联合检测提高诊断率的依据和监测病情变化的价值。方法:对293例肺癌患者年龄38～81岁,男女比例3:1,均来自2002年12月至2006年11月我院门诊和住院患者,进行NSE、D-二聚体、CEA、IL-6R水平的检测,将293例患者分为:早期肺癌组98例,晚期肺癌组195例,非小细胞肺癌(non-small cell lungcancer,NSCLC)组202例,小细胞肺癌(small cell lung cancer,SCLC)组91例,患者治疗前138例,治疗后155例,健康查体者选300例作为正常组作对照,年龄35至80岁,男女比例3:1,采用酶联免疫法对293例肺癌患者的血标本进行神经元烯醇化酶(NSE)、癌胚抗原(CEA)、白介素-6受体(IL-6R)、D-二聚体(D-Dimer)四项含量检测。结果:早期肺癌组CEA、NSE、IL-6R含量均高于健康对照组(P<0.01),而D-Dimer在早期肺癌患者中与健康对照组比较差异不显著(P>0.05),晚期肺癌组CEA、NSE、IL-6R、D-Dimer的含量均高于早期肺癌组(P<0.01),NSCLC组CEA、IL-6R、D-Dimer的含量均高于SCLC组(P<0.01)而NSE小于SCLC组,治疗前CEA、NSE、IL-6R的含量均高于治疗后(P<0.01)。阳性诊断率分别为四项同时检测81.6%、NSE、CEA、IL-6R三项检测78.2%、NSE、CEA两项检测61.8%、NSE-项检测48.5%。结论:CEA、NSE、IL-6R、D-Dimer四项联合检测比单项检测阳性诊断率高,且对肺癌分型诊断有一定的价值,特别对无症状早期肺癌诊断和肺癌的病情观察有很高的临床价值。
Objective： To discuss the values of tumor markers in diagnosis and predicting prognosis in lung cancer by united test of NSE,CEA,IL-6R and D-Dimer. Methods： 293 cases of lung cancer were selected from December 2002 to November 2006,aging from 38 to 81 years old. The ratio of male to female was 3： 1. The patients were divided into four groups：early lung cancer of 98 cases,lately lung cancer of 195 cases;non-small cell lung cancer of 202 cases, small cell lung cancer of 91 cases. Pre-treated patients were 138 cases, post-treated patients were 155 cases. Healthy control group was 300,aging from 35 to 80 years old,the ratio of male to female was 3= 1. The level of NSE,CEA,IL-6R and D-Dimer were determined by ELISA. Results： The level of NSE,CEA and IL GR had significantly difference hetween the patients in early hmg cancer group and control group （P〈0.01）, while D-Dimer was not significantly difference （P〉0.05）. The level of NSE,CEA,IL-6R and D-Dimer in advanced lung cancer was higher than those in early lung cancer（P〈0.01） . The level of CEA,IL-6R and D-Dimer in non-small cell lung cancer group was higher than those in small cell lung cancer group（P〈0.01）,while NSE was lower. The level of NSE,CEA and IL-6R of pre-treated patients was higher than those of post-treated patients （P〈0.01）. The positive diagnosis rate were 81.6%（when four indexes were tested in the same time） ,78. 2%（when NSE,CEA and IL-6R were tested）,61.8% （when NSE and CEA were tested）, and 48.5 （when NSE were tested）. Conclusion： While NSE,CEA, IL-6R and D-Dimer were unite tested,there is a higher positive diagnosis. And the measurement of the tumor markers is helpful to determine lung cancer lype, diagnose lung cancer early,and observe the information of illness development.
出处
《中国医药导刊》
2008年第1期124-126,共3页
Chinese Journal of Medicinal Guide
关键词
肺痛
标记物
肿瘤
酶联免疫吸附测定
Lung cancer
Marker
Tumor
Enzyme-linked immnosorbent assay
