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小檗碱和葛根素对卵巢颗粒细胞胰岛素抵抗的调控 被引量：9

Beneficial Effect of Berberine and Daidzein on Insulin Resistance in Ovarian Granulose Cells Induced by Dexmethasone
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摘要 建立了体外的卵巢胰岛素抵抗模型。从卵巢内分子水平探讨胰岛素信号传导和促性腺激素信号传导的相互关系,揭示多囊卵巢综合征患者糖代谢异常和生殖功能障碍的关系;通过药物筛选得出两味中药增敏剂,与西药增敏剂进行了对照研究,探讨了其对卵巢颗粒细胞功能的影响。 Ovarian granulosa cells from porcine follicles were isolated and cultured in vitro for determination of the insulin resistance, by expressions of insulin signal molecules and gonadotropin-releasing hormone signal transduction, and to establish the relations between glucose metabolic disorders and reproductive dysfunction in polycystic ovary syndrome. A comparison was made between insulin-sensitizing western medicines and two traditional Chinese medicines berberine （Ber） and daidzein （Dai） in their improvement effects on insulin sensitivity, and the effects on function of the ovarian granulose cells.
作者 姚晶萍 邱学敏 高磊 吴效科 侯丽辉 倪延群
机构地区 哈尔滨医科大学附属肿瘤医院妇科 黑龙江中医药大学附属第一医院妇产和核医学科 哈尔滨市社会保险局医院
出处 《科技导报》 CAS CSCD 2008年第9期37-41,共5页 Science & Technology Review
基金 中国-芬兰科学技术合作基金项目(FINSINO566) 国家自然科学基金项目(30572404) 黑龙江省自然科学基金重点项目(ZJY0506-01)
关键词 卵巢颗粒细胞 胰岛素抵抗 地塞米松 生殖 中药 ovarian granulose cell insulin resistance dexmethasone reproduction traditional Chinese medicine
分类号 R285 [医药卫生—中药学]
  • 相关文献

参考文献13

  • 1Wu X K, Zhou SY, Sallinen K, et al. selective ovarian resistance to insulin signaling in women with polycystic ovary syndrome [J]. Fertil Steril, 2003, 80: 954-65.
  • 2Wu X K, Sallinen K, Anttila L, et al. Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls[J]. Fertil Steril, 2000, 74: 564-72.
  • 3Kokk K, Verajankorva E, Wu X K, et al. Immunohistochemical detection of glucose transporters class Ⅰ subfamily in the mouse, rat and human testis[J]. Medicina, 2004, 40: 156-161.
  • 4Gueripel X, Benahmed M, Gougeon A S, et al. Gonadotropin treatment of immature mice leads to amplification of transforming growth factor action, via upregulation of receptor-type 1, Smad 2 and 4, and Downregulation of Smad 6[J]. Biology of Reproduction, 2004, 70: 640-648.
  • 5Carolyn M, Komar C. Perocisome proliferators-activated receptors (PPARs) andovarian function-implications for regulating steroidogenesis, differentiation, and tissue remodeling [J]. Reproductive Biology and Endocrinology, 2005, 3: 41-55.
  • 6Nelson-Degrave V L, Jessica K W, et al. Alterations in mitogen-activated protein kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome[J]. Molecular Endocrinology, 2005, 19 (2): 379-390.
  • 7Mihm M, Baker J P, Ireland J, et al. Molecular evidence that growth of dominant follicles involves a reduction in follicle stimulating hormone- dependence and an increase in luteinizing hormone-dependence in cattle[J]. Biology of Reproduction, 2006, 10: 105-138.
  • 8Carolyn M, Komar J, et al. Peroxisome proliferators-activated receptors (PPARs) and ovarian function-implications for regulating steroidogenesis, differentiation, and tissue remodeling [J]. Reproductive Biology and Endocrinology, 2005, 3: 41-55.
  • 9Kalsas G A, Isidori A M, Besser G M, et al. Secondary forms of polycystic ovary syndrome[J]. Trends Endocrinol Metab, 2004, 15: 204-210.
  • 10庆方,潘竞锵,肖柳英,韩超.葛根素对胰岛素抵抗-高血压大鼠胰岛素敏感性的增强作用和降糖降脂作用[J].中医研究,2006,19(3):14-17. 被引量：14

二级参考文献29

  • 1李光伟,Step.,L.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660. 被引量：2127
  • 2郭建平,孙其荣,周全.葛根药理作用研究进展[J].中草药,1995,26(3):163-165. 被引量：203
  • 3Hotta K, Funahashi T, Bodkin N L, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.Diabetes, 2001, 50(5):1126.
  • 4Kubota N, Terauchi Y,Yamauchi T,et al.Disruption of adiponectin causes insulin resistance and neointimal formation.J Biol Chem,2002,277:25863.
  • 5Bogan J S, Lodish H F. Two compartments for insulin-stimulated defined by endogenous ACRP30 and GLUT4. J Cell Biol,1999,146:609.
  • 6Smith U, Axelsen M, Carvalho E,et al. Insulin signaling and action in fat cells: associations with insulin resistance and type 2 diabetes.Ann N Y Acad Sci,1999,892:119.
  • 7李光伟.胰岛素敏感性评估及应用[A].李秀钧主编.胰岛素抵抗综合征[M].北京:人民卫生出版社,2001.44.
  • 8Tremblay F, Lavigne C, Jacques H, et al. Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GluT-4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats. Diabetes,2003, 52:29-37.
  • 9Cho H, Mu J, Kim JK,et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science,2001,292:1728-1731.
  • 10Ferrannini E,Buzzigoli G,Bonadonna R,et al.Insulin resistant in essentral hypertersilon[J].N Engl J med,1987,317:350.

共引文献57

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引证文献9

二级引证文献119

科技导报
2008年 第9期

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