摘要
１８例胆汁反流性胃炎病人（ＢＲＧ组）和１７例非胆汁反流性胃炎病人（ＮＲＧ组），１０名健康志愿者（ＨＣ组）进行双核素胃排空检测，用γ照相机以１帧／２ｍｉｎ连续动态照相１２０ｍｉｎ，根据拟合曲线计算固相延滞期（ＳＬＰ）、滞后期半排空时间（ＨＳＥＴ）和液体半排空时间（ＨＬＥＴ）。于餐前和餐后３０ｍｉｎ、１２０ｍｉｎ抽取外周血测定血浆促胃液素（Ｇａｓ）的浓度。结果：ＢＲＧ组有明显的固、液体双相排空延迟，以ＳＬＰ延长较为突出，而ＨＳＥＴ延长在很大程度上受到ＳＬＰ延长的影响；ＮＲＧ组仅有ＨＳＥＴ显著延长。三组于餐后３０ｍｉｎＧａｓ均明显增高，ＢＲＧ组基础状态下Ｇａｓ有增高趋势餐后１２０ｍｉｎ仍维持在较高水平。结论：胃排空结果提示胆汁反流性胃炎有较严重的胃窦功能不良，Ｇａｓ可能是胃潴留和胆汁反流刺激的一种继发性改变。
We investigated the patterns of gastric emptying for solid and liquid, and plasmic gastrin levels, to explore the possible mechanisms of gastric motility disorders in the pathogenesis of bile reflux gastritis. 18 patients with bile reflux gastritis (BRG), 17 patients with non reflux gastritis (NRG) and 10 healthy controls (HC) were choosed for this study. The patients with bile reflux gastritis showed a significant prolongation of SLP, HSET and HLET. Patients with non reflux gastritis also showed prolonged HSET when compaired with group HC( P <0 05),while parameters of SLP and HLET revealed no statistical difference between these two groups. Increment of gastrin levels were observed in all the three groups, but higher basal and meal stimulating gastrin releases were only found in group BRG. It is concluded that patients with BRG have a notable delay in gastric emptying for both solid and liquid. Dysfunctional antrum fails to effectively evacuate the excessive refluxates and incurred prolonged retention after meal, which possibly causing high gastrin release, may play a critical role in the pathogenesis of bile reflux gastritis.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1997年第5期318-320,共3页
Medical Journal of Chinese People's Liberation Army
