摘要
目的探讨环氧化酶Ⅱ（COX-2）在非小细胞肺癌（NSCLC）组织中的表达及其与NSCLC发生、发展关系。方法采用免疫组织化学法检测45例NSCLC组织和癌旁正常组织标本COX-2的表达水平。结果COX-2在NSCLC组织的表达率为64．4％（26／45），明显高于癌旁正常组织的31．1％（13／45），两者比较差异有统计学意义（P〈0．05）。COX-2表达在不同性别、年龄及组织分化间差异无统计学意义（P〉0．05）；C0X-2表达在腺癌明显高于鳞癌（P〈0．05），直径〉3cm肿瘤组织明显高于直径≤3cm肿瘤组织（P〈0．05），有淋巴结转移者明显高于无淋巴结转移者（P〈0．05），TNM分期Ⅲ＋Ⅳ期者明显高于Ⅰ＋Ⅱ期者（P〈0．05）。结论COX-2参与了肺癌发生、发展过程。
Objective To explore the expression of cyclooxygenase-2（COX-2） in non-small cell lung cancer （NSCLC） and its relationship with NSCLC development. Methods Expression of COX-2 protein was detected in 45 cases of NSCLC tissues and 45 cases of paracancerous tissues by immunohistochemistry assay. Results Expression of COX-2 was detected in a significantly greater proportion of NSCLC tissues（64.4 % ） than that of paracancerous tissues（31.1% ）（ P 〈0.05）;expression of COX-2 in different gender, age and tissue differentiation was no significant difference（P〉0.05）;expression of COX-2 in adenocarcinoma was obviously higher than that in squamous carcinoma（P〈0.05）;expression of COX-2 in the diameter of carcinoma tissue above 3cm was significantly higher than that below 3cm（P〈0.05） ;expression of COX-2 in carcinoma tissue existing lymphnode metastasis was obviously higher than that in non-existing lymphnode metastasis（P〈0.05） ; expression of COX-2 in stage Ⅲ-Ⅳ of TNM was significantly higher than stage Ⅰ＋Ⅱof TNM（P〈 0.05）. Conclusion COX-2 was involved in occurrance and development process of lung cancer.
出处
《中国基层医药》
CAS
2008年第4期550-551,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
癌
非小细胞肺
环氧化酶-2
Corcinoma, non-small-cell lung
Cyclooxygenase 2
