摘要
目的探讨D-二聚体、凝血酶．抗凝血酶复合物、纤溶酶．抗纤溶酶复合物、蛋白C在急性呼吸窘迫综合征（ARDS）诊断中临床意义，并为ARDS治疗过程提供血清学依据。方法实验组选取105例符合ARDS诊断标准患者（对照组选取健康献血员）分别采静脉血，进行凝血酶原时间、凝血酶时间、部分凝血活酶时间、血小板计数、D-D、TAT、PAP、PC八项血清指标的定量测定。结果ARDS的患者血浆中D．D、TAT、PAP、PC的含量与对照组进行比较，差异有统计学意义（P〈0．01）。结论D．D、TAT、PAP、PC浓度在ARDS患者中有明显变化，而PT、TT、APTT、Pt的含量变化不明显。提示在ARDS早期给予抗凝治疗有一定的临床价值。
Objective To measure D-Dimer （DD）. thrombin-antithrombin complex （TAT）, lasmin-antiplasrain complex（PAP） and protein C（PC） in ARDS,to find the clinical significance of them,discuss the objective base in the early diagnosis of ARDS in the lab, and offer the serologic bases in the treatment and prognosis of ARDS. Methods 105 patients of ARDS were selected as the study group, and 105 people were selected as the control group, all of whom were healthy with no thrombus diseases. The venous blood of everyone in both groups was sampied,in order to take a quantitative determination of plasma prothrombin time（PT）, prothromhin time（＇lT）, kadin partial thromboplastin time（APTT）, the amount of blood platelet,DD, TAT, PAP, PC. Results Serum concentrata- tion of D-D,TAT, PAP was significantly higher in patients in ARDS group than that in control group （P 〈 0.01 ）. Serum concentratation of PC was significantly lower in patients in ARDS group than that in control group （P 〈 0.01 ）. Conclusion Measuring the concentration of DD,TAT, PAP and PC was very important,which not only did good to the early diagnosis of ARDS, but also had a clinic value.
出处
《中国基层医药》
CAS
2008年第4期541-542,共2页
Chinese Journal of Primary Medicine and Pharmacy
