摘要
微小RNA（miRNA）是小分子RNA家族中的一员，内源性非编码基因构成的21～23nt单链小RNA分子，在生物进化过程中保持了高度的保守性，通常由Dicer酶从具有发夹二级结构的RNA前体加工而来，miRNA虽然微小，但它在真核生物发育和基因表达中通过与靶mRNA形成完全或不完全互补配对从而扮演着重要角色。2004年，发现了编码和表达miRNA的第一个病毒——埃博拉病毒（epstein-barrvirus，EBV），最近，miRNA又从肉瘤相关疱疹病毒（kaposi’s sarcoma-as-sociated herpesvirus，KSHV）和人巨细胞病毒（human cytomegalovirus，HCMV）中克隆到，此外，SV40 miRNA被认为负调控T抗原（1arge T-antigen，T Ag）表达，作者对病毒编码的miRNA及miRNA在最近研究中的预测、表达和功能作一综述。
MicroRNAs （miRNA） ,one of the small moleculay RNA family, are single strand endogenous noncoding 21 to 23 nueleotide RNA molecules that keep high conservation in the process of evolution. Although they are tiny,In eukaryotes,microRNAs played important roles in the course of development and gene expression regulation, typically by forming perfect or imperfect duplexes with target messenger RNAs. In 2004, Epstein-Barr virus, was the first virus shown to encode and express miRNAs. Recently, miRNAs have also been cloned from Kaposi＇s sarcoma-associated herpesvirus, mouse γ-herpesvirus-68 and human cytomegalovirus. In addition, the SV40 miRNA have been shown to negatively regulate large T-antigen （TAg） expression. This review will summarize recent findings on the prediction, expression and functions of miRNA and virally encoded miRNAs.
出处
《中国畜牧兽医》
CAS
2008年第5期57-60,共4页
China Animal Husbandry & Veterinary Medicine
