摘要
目的了解慢性乙型肝炎病毒基因型与临床及病理表现的相互关系。方法对92例慢性乙型肝炎患者进行HBV基因分型，并与其临床生化结果、病毒定量和肝组织病理进行相关性分析。结果B基因型16例（17.4％），C基因型71例（77．2％），B＋C混合型3例（3．2％），未分出型2例（2．2％），其中B和c基因型在丙氨酸转氨酶水平分别为（82．6±82）U／L和（84．7±71．5）U／L，病毒复制水平Log值分别为（5．8±1．4）和（5．9±1．5），C型患者中有8例病理诊断为肝炎肝硬化，但均无统计学意义。结论B型和C型慢性肝炎患者在丙氨酸转氨酶、病毒复制、HBeAg表达水平及肝脏病理炎症和纤维化程度间差异无统计学意义。
Objective To explore the relationship between chronic hepatitis B virus genotypes and clinical pathology. Methods HBV genotype was determined in 92 cases with chronic hepatitis B patients and the relationship between HBV genotypes and clinical, serological and histological data of the patients was analyzed. Results Sixteen cases were infected with HBV genotype B （17.4%）, 71 with genotype C （77.2%）, 3 with HBV classified as genotype B ＋ C （3.2%） and in 2 （2.2%） cases HBV genotype was not confirmed. ALT level andHBV DNAloadlog value were （82.6±82） U/L, （84.7± 71.5） U/L and （5.8±1.4）, （5.9±1.5） respectively in genotypes B and C patients, in 8 cases of genotype C group liver cirrhosis was diagnosed, but no statistical significance was seen. Conclusion No significant differences in clinical, serological or histological data were detected between genotypes B and C patients.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2008年第2期116-118,共3页
Chinese Journal of Experimental and Clinical Virology
