摘要
应用免疫组织化学双标记技术对急性轻型和慢性活动型乙型病毒性肝炎各２０例活检肝组织中的Ｆａｓ抗原和增殖细胞核抗原（ＰＣＮＡ）进行了检测。Ｆａｓ抗原表达于肝细胞胞浆内，急、慢性肝炎肝组织中Ｆａｓ抗原检出率分别为６０．０％及８０．０％，ＰＣＮＡ于肝细胞核内表达，其检出率均为８５．０％。两种抗原阳性细胞可各自弥散分布于肝小叶内，但在点灶性和碎屑状坏死灶周围较为密集多见。结果表明，病毒性肝炎时肝组织中Ｆａｓ抗原和ＰＣＮＡ的分布密切相关，肝细胞损伤愈明显，其再生修复能力也愈强。
Liver biopsy specimens of 40 cases,including 20 cases of acute and 20 cases chronic active hepatitis B,were immunohistochemically stained for Fas antigen and proliferating cell nuclear antigen(PCNA).Fas antigen was expressed in hepatocellular cytoplasm and PCNA in nucleus.The positive detection of Fas antigen was 60.0% and 80.0% in acute and chronic hepatitis,respectively.The percentage of PCNA was same in both type hepatitis(85.0%,17/20).The positive cells of each antigen were seattered in lobule,but more concentered near local or piecemeal necrosis.Result showed that the relation of distribution between Fas antigen and PCNA is rather closed in hepatitis,the more damage of hepatocytes,the more regeneration.
出处
《临床肝胆病杂志》
CAS
北大核心
1997年第4期196-198,共3页
Journal of Clinical Hepatology
关键词
增殖细胞核抗原
免疫组织化学
乙型肝炎
Fas antigen Proliferating cell neclear antigen Hepatitis B Immunohistochemistry
