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过氧化物酶体增殖物激活受体与动脉粥样硬化研究进展 被引量：2

Research progress on peroxisome vegetation-activating receptor and artherosclerosis
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摘要 过氧化物酶体增殖物激活受体(peroxisome proliferator activated receptors,PPARs)属于核受体超家族配体激活的转录因子,经转录激活靶基因,可影响脂质代谢、糖稳态、细胞增殖、分化和凋亡,以及炎症反应。目前,动脉粥样硬化被认为是一种慢性炎症反应。因此,PPARs激活通过调节新陈代谢及抗炎的双重作用影响动脉粥样硬化的发展。本文综述PPARs的结构和分布、PPARs配体、PPARs与动脉粥样硬化的关系。
作者 杨秀云 陶剑虹 蔡力
机构地区 四川省人民医院心内科
出处 《实用医院临床杂志》 2008年第3期99-102,共4页 Practical Journal of Clinical Medicine
关键词 过氧化物酶体增殖物激活受体 动脉粥样硬化 炎症
分类号 R543.5 [医药卫生—心血管疾病]
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  • 4Jackson SM,Parhami F,Xi XP,et al.Peroxisome proliferatoractivated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.Arterioscler Thromb Vasc Biol,1999,19:2094-2104.
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实用医院临床杂志
2008年 第3期

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