摘要
目的:探讨芍药甘草附子汤对类风湿性关节炎的作用机理。方法:48只Wistar大鼠随机分为空白对照组、模型组、雷公藤多甙组、芍药甘草附子汤组。除空白组外,各组大鼠复制类风湿关节炎模型,连续灌胃给药21天,采血测定白介素-1β(IL-1β)、前列腺素E2(PGE2)水平,取左踝关节组织观察病理改变。结果:芍药甘草附子汤组血清中IL-1β、PGE2明显降低,与模型组比较有显著性差异。关节病理损害明显改善。结论:芍药甘草附子汤能够降低IL-1β、PGE2含量从而减轻其对关节的侵害。
Objective： To investigate the mechanism of the therapy of Paeoniae and Glycyrrhizae and Aconiti Decoction （PGAD） on the rheumatoid arthritis. Methods ： Forty - eight Wistar rats were divided into normal comparison group, model group, Tripterygium Wilfordii Hook. f group and PGAD group at random. Except the normal comparison group, the others were fabricated Adjuvant Arthritis（ AA） model. After treated the model rats for 21 days. Collected the blood of all rats to measure the level of Interleukin - 1β （ IL - 1β） and Prostaglandin E2 （ PGE2 ）. And histopathology change of left malleolus joint were observed through light microscope. Results ： PGAD can reduce the content of IL - 1 and PGE2 , And relive the histopathology change of malleolus joint, which were statistically significant compared to those of model group, Conclusion ： PGAD can reduce the content of IL - 1β and PGE2 to lessen their destroy of the joint.
出处
《中华中医药学刊》
CAS
2008年第5期1081-1083,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
芍药甘草附子汤
类风湿性关节炎
IL-1Β
PGE2
Paeoniae and Glycyrrhizae and Aconiti Decoction （PGAD）
Rheumatic Arthritis
IL - 1β
PGE2
