摘要
目的：研究肿瘤坏死因子（ＴＮＦ）在急性脑梗塞时的变化及其意义。方法：用放射免疫方法测定３２例急性脑梗塞患者的血清ＴＮＦ水平及白细胞（ＷＢＣ）计数。结果：急性脑梗塞时患者血清ＴＮＦ显著增高〔（２３．６７±３．３２）ｐｍｏｌ／Ｌ〕，与正常对照组〔（８．１６±３．５６）ｐｍｏｌ／Ｌ〕比较有显著性差异（Ｐ＜０．０１）；ＴＮＦ在梗塞发生后第１、５、１０及１４日呈持续性增高，其中以第５日为最高（３０．７４±６．３３）ｐｍｏｌ／Ｌ；第１日时ＴＮＦ与ＷＢＣ呈一致性改变。结论：急性脑梗塞后的ＴＮＦ持续性增高与脑梗塞后的ＴＮＦ双重合成有关，ＴＮＦ引发的血管内皮细胞白细胞血小板环路激活过程是脑缺血性损害的基本病理过程。
Objective:To investigate change in tumor necrosis factor (TNF) level and its significance in patients with acute cerebral infarction.Methods:TNFlevels and white blood cell (WBC) count were determined in 32 patients with acute cerebral infarction by radioimmunoassay.Results:Levels of TNF were significantly increased in patients with acute cerebral infarction (23 67±3 32)pmol/L ,and it was much higher than that in the control group (8 16±3 56)pmol/L, P <0 01 .Also,a persistent elevation of TNF was found in patients on day 1,5,10,14 after cerebral infarction,peaking on day 5 postinfarction (30 74±6 33)pmol/L .In addition,change in TNF level paralleded with WBC count on day 1 after cerebral infarction.Conclusions:The continuous increase of TNF may be related to its double way in TNF production,and activation of endothelial cellWBCplatelet pathway plays an important role in the pathogenesis of cerebral lesion.
出处
《中国危重病急救医学》
CAS
CSCD
1997年第11期655-657,共3页
Chinese Critical Care Medicine
关键词
脑梗塞
急性
肿瘤坏死因子
白细胞
cerebral infarction
tumor necrosis factor
white blood cell
