摘要
观察中药肺宁对博莱霉素诱导的小鼠肺纤维化的治疗作用。以博莱霉素气管内注入建立肺纤维化模型,次日始分别给予中药肺宁和强的松灌胃治疗,于给药后56天处死动物,对肺组织行病理组织学检查。与模型组相比,肺宁高、中剂量组肺泡炎症程度显著降低(P<0.05),肺宁高剂量组肺纤维化等级明显减轻(P<0.05)。肺宁可减轻肺损伤小鼠的炎症反应,能够对博莱霉素诱导的小鼠肺纤维化起到治疗作用。
To study the effect of Chinese medicine Feining on experimental pulmonary fibrosis in rats induced by Bleomycin（ BL）, All rats were randomly divided into control groups, model groups, Feining groups（ dose ：1 g/ kg; 2 g/kg; 4 g/kg）, prednisone groups and given BL endotracheally except the normal control group. On day 2, each BL group was given Feining and prednisone respectively except BL control group. After 56 days, 10 rats in each group were killed and lungs were harvested. The lungs were subjected to histopathological studies. Compared to model group, alveolitis was alleviated in Feining（4 g/kg;2 g/kg） group significantly （P 〈0.05 ）, and the rank of pulmonary fibrosis was also alleviated in Feining （4 g/kg） group group rats significantly （ P 〈 0.05 ）. Feining can alleviate pulmonary alveolitis and resist pulmonary fibrosis.
出处
《科学技术与工程》
2008年第7期1785-1787,共3页
Science Technology and Engineering
关键词
肺宁
博莱霉素
肺泡炎
肺纤维化
feining bleomycin pulmonary alveolitis pulmonary fibrosis
