摘要
目的:探讨Ⅱ型糖尿病(non-insulindependentdiabetesmellitus,NIDDM)中医证型与脂质过氧化反应之间的关系。方法:测定了61例不同中医证型NIDDM患者血清超氧化物歧化酶(SOD)活力与丙二醛(MDA)含量,并与20名健康者作对照比较。结果:NIDDM组比对照组SOD活力明显降低(P<0.01),MDA含量明显升高(P<0.01);随阴虚热盛、气阴两虚、阴阳两虚证型顺序或无血瘀兼证到有血瘀兼证顺序,患者SOD活力逐步降低,MDA含量逐步升高。结论:NIDDM患者体内抗氧化能力下降,脂质过氧化反应增强,这与中医证型有密切关系,通过检测患者血清SOD与MDA可为辨证分型作参考并可作为判断病情轻重的一项客观指标。
Objectlve:To explore the possible relationship between Syndrome-Type in TCM and the superoxide dismutase(SOD)as well as malonyldialdehyde(MDA).Methods:Serum SOD and MDA were measured in 6l patients withnon-insulin dependent diabetes mellitus(NIDDM)and 20 normal subjects.Results;SOD activity of the NIDDMpatients blood were clearly lower than those of normal subjects,but MDA were markedly elevated.From the Syn-drome-Type of Yin Deficiency with Hyperactivity of Heat,to both Qi and Yin Deficiency,to both Yin and Yang De-ficiency,or from without hemostasis to with the appearance of hemostasis in order.The SOD activity decreased andmeanwhile MDA increased gradually.Conclasions:SOD activity and MDA levela in patients with NIDDM were as-sociated with Syndrome-Type in TCM,it might be responsible for the diagnosis of Syndrome-Type in TCM.
作者
姜兆顺
张胜兰
晏辉
蔡新吉
杨丁友
JIANG Zhao-shun;ZHANG Sheng-lan;YAN Hui(General Haspital of Jinan Military Region,Peoples Liberation Army,Jinan 250031)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第10期597-598,共2页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
Ⅱ型
糖尿病
中医证型
超氧化物歧化酶
丙二醛
non-insulin dependent diabetes mellitus
Syndrome-Type in TCM
superoxide dismutase
malonyl-dialdehyde
