摘要
目的用循证医学的方法评价大黄辅助治疗重症急性胰腺炎的疗效。方法检索1966年到2007年5月间发表的有关大黄辅助治疗重症急性胰腺炎疗效的随机对照临床试验。按入选和排除标准,有12项临床试验纳入本研究,由2名评价者对入选研究中有关试验设计、研究对象的特征、研究结果等内容独立进行摘录,用RevMan4.2软件进行分析。结果大黄灌胃灌肠辅助治疗组的肠鸣音恢复时间(WMD=-2.40,95%CI:-3.70^-1.09,P<0.01)、首次排便时间(WMD=-4.73,95%CI:-6.58^-2.89,P<0.01)、腹痛缓解时间(WMD=-5.30,95%CI:-11.23^-0.63,P<0.01)、住院天数(WMD=-13.03,95%CI:-19.73^-6.33,P<0.01)、病死率(Or=0.35,95%CI:0.17~0.76,P<0.01)均明显低于对照组,且均差异有极显著性。结论大黄灌胃灌肠辅助治疗能显著缩短重症急性胰腺炎患者的肠鸣音恢复时间、首次排便时间、腹痛缓解时间、住院天数,明显降低病死率。
Objective The aim of this study is to evaluate the effectiveness of rhubarb in the treatment of severe acute panereatitis according to a systematic review and meta-analysis. Methods The articles published on May of 1966 - 2007 about the randomized controlled clinical trials of rhubarb on severe acute panereatitis were searched for. According to the criteria of selection and exclusion ,twelve studies were enrolled into the analysis. The details about the trial designing, characters of the subjects, results were reviewed by two independent evaluators and analyzed by using Revman 4.2 software. Results Compared with the control group, patients treated with rhubarb were showed significantly shorter period of bowel sound recovery （ WMD = - 2.40,95% CI ： - 3.70 - - 1.09,P 〈 0.01 ） , lower time of the first defecation （ WMD = - 4.73,95 % CI ： - 6.58 - 2.89,P 〈 0.01 ） , quicker stomachache relief （ WMD = - 5.30,95% CI ： - 11.23 - - 0.63, P 〈 0.01 ）, less hospital stay （ days ） （ WMD = - 13.03,95 % CI ： - 19.73 - - 6.33, P 〈 0.01 ） and lower hospital death （ O r = 0.35,95 % CI ： 0.17 - 0.76, P 〈 0.01 ）. Condusion The systematic review and meta-analysis shows that the adjunctive therapy with rhubarb can decrease the bowel sound recovery time, the first defecation time, the stomachache relief period, hospital stay （days） and hospital death.
出处
《医药导报》
CAS
2008年第5期549-552,共4页
Herald of Medicine
