摘要
目的:观察用异烟肼预处理后大鼠吸入七氟醚后血清谷丙转氨酶(SGPT)及肝病理学的变化,以研究酶诱导对七氟醚肝毒性的影响。方法:将40只月龄2～3月的SD大鼠随机分为对照组(C组),异烟肼组(Ⅰ组),酶诱导的七氟醚组(SI组),未有酶诱导的七氟醚组(S)组.Ⅰ组和SI组每天用异烟肼预处理25mg·kg^(-1)腹腔注射,持续三天。SI组和S组吸0.5MAC七氟醚3小时,C组和Ⅰ组吸O^2和空气混合气体。结果:SI组SGPT浓度(162.0±25.3)明显高于C组(115.8±41.8)、Ⅰ组(121.6±42.9)和S组(126.2±26.2)(P<0.05),且该组肝细胞疏松化程度较其它各组严重。结论:酶诱导有增加七氟醚肝毒性的可能。
Objective:To test the effects of enzyme-induced with isoniazid on the sevoflurane hepatoxicity. Method: Forty SD rats were assigned randomly to four groups: control group (C), isoniazid-treated group (Ⅰ), enzyme-induced sevoflurane group (SI) and nonenzyme-induced sevoflurane group (S). Group I and group SI received 25mg·kg^(-1) isoniazid i. p. per day for three days. The rats of group S and group SI was exposed to 0.5 MAC sevoflurane for three hours. Result: The levels of serum glutamate-pyruvate transminase(SGPT) were 115.8±41.8 in group C, 121.6±42.9 in group I, 126.2±26.2 in gruop S and 162.0±25.3 in group SI. The level of SGPT in group SI was significantly higher than that of other groups The ultrastructure showed that the degree of liver injury of group SI was the most serious among these groups. Conclusion:The enzyme induction may have the possibility of increasing the hepatotoxicity of sevoflurane.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1997年第10期610-612,共3页
Chinese Journal of Anesthesiology
基金
江苏省教委资助课题
关键词
异烟肼
七氟醚
肝毒性
酶诱导
Isoniazid
Sevoflurane
Hepatotoxicity
Enzyme induction
