摘要
采用聚合酶链反应（ＰＣＲ）技术对１９８７年７月～１９９６年６月接受男性供肾的５７例女性受者的嵌合状态进行研究。发现嵌合总发生率为５４．４％（３１／５７）；生存期３年以上的受者嵌合发生率为６６．７％（１８／２７），而三年以内嵌合发生率为４３．３％（１３／３０），两者差异有显著性（Ｐ＜０．０５）；肾移植后２个月内，嵌合的形成尚不稳定。结果表明：随着肾移植受者生存期的延长，嵌合的发生率相应增高；嵌合反映了供者器官与受者免疫系统之间双向作用的关系，并与免疫耐受存在某种联系。
Peripheral blood chimerism in 57 female renal allograft recipients was studied. It was found that chimerism was detected in 54.4%(31/57) of recipients; in recipients survive beyond 3 years, chimerism was detected in 63.6%(18/27); while in those within 3 years, it was detected in 43.3% (13/30) ( P <0.05). Within the first 2 months after transplantation, chimerism was unstable. The results revealed that chimerism was more frequently detected in recipients with long term graft survival. Chimerism was a reflection of interaction between the recipient and the transplanted kidney, and might be related to the induction of immunological tolerance.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1997年第9期527-529,共3页
Chinese Journal of Urology
