摘要
目的：细胞凋亡（Ｆａｓ）参与免疫调节及清除病毒，本文就Ｆａｓ与慢性肝病中组织学活动指数、谷丙转氨酶及乙型肝炎病毒脱氧核糖核酸的关系作一分析，以期了解Ｆａｓ在慢性肝病中的意义。方法：以Ｋｉｙｏｓｈｉ半定量法对４９例慢性肝病患者肝组织的Ｆａｓ表达进行了分析，部分患者进行了随访。其中慢性活动性肝炎（ＣＡＨ）２５例，肝硬化（ＬＣ）６例，原发性肝癌（ＨＣＣ）１８例。结果：２５例ＣＡＨ中１８例占７２％阳性，多呈弥漫型分布。门脉或门脉周围炎症重者阳性信号明显。ＡＬＴ升高、ＨＡＩ分值高者Ｆａｓ呈高表达。在ＣＡＨ细胞凋亡和坏死并存。原发性肝癌癌组织的Ｆａｓ表达为片状或点状分布。ＩＮＦ治疗后肝组织Ｆａｓ表达增虽。
Aim:Fas and Fas ligand play an important role in regulating normal immune responese and viral clearance.The significance of Fas expression in chronic liver diseases was analyzied histologically along with HAI,ALT and HBV DNA in this study.Methodes:Fas expression was examined semiquantatively by methode of kiyoshi.The 49 cases of chronic liver disease,including 25 of CAH,6 of cirrhosis and 18 cases of HCC,seven cases of CAH treated by INF α2b,the expression of Fas were followed up.Results:of the 25 cases of CAH the Fas were detected positive in 18(72%),most of the Fas were of the diffusive type,the inflammatory signal were conspicuous around the portal and periportal zone.The ALT were elevated,HAI scored high and the expression of Fas were significant.The apoptosis and necrosis were coexisted in these cases of CAH,The Fas expression in the cases of HCC were of the circumscribed or spotted type.It was noted that Fas expression often enhanced after the INF treatment.Conclusions:Fasmediated apoptosis along with necrcsis phay an important role in the pathogenesis of viral hepatitis.
出处
《胃肠病学和肝病学杂志》
CAS
1997年第3期222-223,共2页
Chinese Journal of Gastroenterology and Hepatology
