摘要
目的探讨幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，Ｈｐ）相关性胃炎患者胃液氨对粘膜上皮的毒性作用。方法本研究利用酶法对５６例Ｈｐ阳性慢性胃炎患者胃液氨浓度进行测定，并对此值与粘膜病变的关系进行分析。结果胃液氨浓度与粘膜病变有明显相关性，表现为胃液氨浓度明显增高者，粘膜表面粘液层明显变薄，粘膜上皮萎缩，明显的炎症细胞浸润，肠上皮化生及粘膜微循环淤血。结论Ｈｐ相关性胃炎胃液氨是粘膜损伤的主要因素之一。
ims:to identify the toxic effect on gastric mucosa by ammonia derived from urea by cellconfined urease activity of Helicobacter pylori(Hp).Methods:83 consecutive patients undergoing electron gastroscope were included in the study.Six biopsies of gastric mucosa from each patient were obtained during the examination.Ammonia concentration in gastric juice were determined by enzyme method.Results The ammonia concentration in 56 Hppositive patients were significantly higher than those in Hpnegative patients (P<0.001).And also the concentrations in Hppositive patients were closely related to the lesions of gastric mucosa.It was presented that the mucus layer on epithelial cells became thinner (P<0.01 or 0.05);the mucosal epithelium got atrophic (P<0.05)and had intestinal metaplasia (P<0.01 or 0.05);there was an obvious inflammatory cell infiltration in mucosa (P<0.002 or 0.001);and the microvascular circulation of the mucosa had obvious stasis (P<0.02 or 0.001) Conclusions:Ammonia in gastric juice plays an important role in the lesions of gastric mucosa in patients with Hppositive gastritis.
出处
《胃肠病学和肝病学杂志》
CAS
1997年第2期136-140,共5页
Chinese Journal of Gastroenterology and Hepatology
关键词
幽门螺杆菌
胃炎
胃液氨
粘膜病变
elicobacter pylori gastritis ammonia mucosal lesions.
