摘要
研究以乙酰乙酸乙酯等原料合成头孢他啶侧链酸及其活性硫酯的方法,即以乙酰乙酸乙酯为起始原料,经肟化、溴化、成环3步反应合成去甲氨噻肟乙酸乙酯[2-氨基-α-羟亚氨基-4-噻唑乙酸乙酯];再经醚化、水解、酰化反应合成其活性硫酯-狖(Z)-2-氨基-α-[[2-(叔丁氧基)-1,1-二甲基-2-氧代乙氧基]亚氨基]-4-噻唑乙酸狚2'-苯并噻唑基硫酯。
The synthetic methods of side chain acid of ceftazidime and activated thioester was studied in this paper. Ethyl（Z）-2-（2-aminothiazol-4-y1）-2-hydroxyimino acetate was prepared from ethyl acetoacetate through oximation, bromination and cyclocondensation, and then the final product, ceftazidime activative thioeste {（Z）-2-amino-α- [ [2-（t-butoxy） -1, 1-dimethyl-2-ox-oethoxy] imino] -4-thiazoleacetic -2-benzothiazolyl thioester}, was obtained through further etherification,hydrolysis and acylation.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2008年第4期206-209,共4页
Chinese Journal of Antibiotics
关键词
头孢他啶
侧链酸
活性硫酯
合成
Ceftazidime
Side chain acid
Activated thioester
Synthesis
