摘要
目的:提高中药注射剂的用药安全性。方法:采用前瞻性多中心随机对照法,选取天津市第一中心医院和天津中医药大学第一附属医院2006年10月～2007年5月的住院病例为研究对象,随机分为对照组和干预组,采用宣传教育、行政干预、监督检查等干预措施,针对适应证因素对中药注射剂应用进行干预,并观察不良反应发生率的变化对干预组与对照组的结果进行分析研究。结果:与对照组比较,干预组中药注射剂使用的适应证更加合理(P<0.05),不良反应的发生率显著降低(P<0.01),临床疗效也显著提高(P<0.01),平均住院费用有所下降。结论:适应证干预后不良反应发生率大大降低,干预有效。
OBJECTIVE： To carry out clinical intervention aimed at indications, and to observe the change in the incidence of adverse drug reactions （ADRs） so as to improve medication safety of Chinese medicine injections. METHODS： In this prospective multi-center randomized control study, the inpatients hospitalized in the First Affiliated Hospital of Tianjin University of TCM between Oct. in 2006 and May in 2007 were enrolled and randomized to control group and intervention group. The intervention measures such as carrying out propaganda and public education, administrative intervention, surveillance and inspection etc were taken aimed at the indications of Chinese medicine injections. The outcomes in the intervention group and the control group were analyzed comparatively. RESULTS： As compared with the control group, the drug use was more rational in the intervention group, which was more in line with indications（P〈0.05）, the incidence of ADRs was significantly lower（P〈0.01）, the clinical efficacy was significantly improved（P〈0.01）, and the average cost of hospitalization was lowered. CONCLUSION： Due to the effective intervention on drug mixing time and indications, the incidence of ADRs has been greatly reduced. It is effective to carrv out intervention on these factors.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第12期942-944,共3页
China Pharmacy
基金
天津市卫生局中医、中西医结合科研专项资金课题(2005023)
关键词
中药注射剂
干预
适应讧
不良反应
Chinese medicine injection
Intervention
Indication
Adverse drug reactions
