摘要
目的:探讨溶血磷脂酸(LPA)及纤维蛋白原(FIB)在缺血性卒中发病中的作用。方法:采用酶联免疫法检测了95例急性期及36例恢复期脑梗死患者,47例颈动脉粥样硬化患者及35名健康者外周血LPA及FIB水平。结果:急性期脑梗死患者LPA及FIB水平均较恢复期脑梗死及颈动脉粥样硬化患者高,P<0.01;恢复期脑梗死及颈动脉粥样硬化患者又较健康对照组高,P<0.01;恢复期脑梗死患者与颈动脉粥样硬化患者相比无统计学意义,P>0.05。结论:LPA及FIB增高不仅是急性脑梗死缺血性损伤反应,而且在颈动脉粥样硬化患者已有增高,它们在缺血性卒中发病中发挥一定的作用。
Objective： To evaluate the role of LPA and FIB inpathogenesis of ischemic stroke. Method： The level of LPA and FIB of peripheral blood in serum were measured in 95 patients with cerebral infarct in acute phase, 36 patients with cerebral infarct in recovery phase, 47 patients with carotid athero sclerosis and 35 healthy controls by ELISA method. Result： The level of LPA and FIB in serum of the patients with cerebral infarct in acute phase were significantly higher than those in recovery phase and carotidatherosclerosis （ P 〈0.01 ） , the level of LPA and FIB in serum of the patients with cerebral infarct in recovery phase and carotid atherosclerosis were significantly higher than those of healthy controls （ P 〈 0. 01 ）, but there were no statistical significances between the patients with cerebral infarct in recovery phase and carotid atherosclerosis （ P 〉 0.05 ）. Conclusion： The increased of LPA and FIB were not merely the response to cerebral ischemic injury, they had abnormal increased in patients with carotid atherosclerosis, they might play some role in the pathogenesis of ischemic stroke.
出处
《河北医学》
CAS
2008年第3期279-281,共3页
Hebei Medicine
