摘要
目的探讨人巨细胞病毒(HCMV)感染与脑梗死患者血管病变关系的可能机制。方法选择首发脑梗死患者101例,根据实验室检查结果分为HCMV阴性组(59例)、HCMV阳性组(42例),同期选择健康体检的HCMV抗体阴性者40例为对照组。检测颈动脉内膜中层厚度(IMT)、HCMV抗体、脂联素、白细胞介素6(IL-6)水平,比较3组IMT、脂联素、IL-6水平。结果HCMV阳性组患者的IMT与其他2组比较有统计学差异(P<0.01);脂联素较其他2组明显降低(P<0.01);IL-6较其他2组明显升高(P<0.01);脂联素与IL-6呈负相关(r=-0.455,P<0.001);IMT与IL-6呈正相关(r=0.339,P<0.001)。结论HCMV感染可能通过升高血清IL-6水平,降低脂联素水平,促进动脉粥样硬化形成、从而诱发脑梗死。
Objective To study the relationship between the cytomegalovirus infection （HCMV） and vasculopathy in patients with cerebral infarction. Methods 101 patients with first stroke attack were divided into two groups：patients without HCMV infection and patients with HCMV infection,meanwhile forty healthy people were selected as control group. The IMT of common carotid artery,levels of serum adiponectin and interleukin-6 were measured and compared between the 3 groups. Results Compared with HCMV negative group and control group,the IMT of the common carotid artery increased significantly （ P 〈 0. 01）, the level of serum adiponectin decreased significantly（ P 〈0.01） and the level of serum interleukin-6 increased significantly in the HCMV positive group（ P 〈0.01）. Correlation analysis showed that the level of serum adiponectin was negatively correlated with the level of serum interleukin-6 （ r = -0. 455, P 〈0. 001） and IMT was positively correlated with the level of serum interleukin-6 （ r =0. 339, P 〈0. 001）. Conclusion The HCMV infection can increase the level of serum interleukin-6 which decreases the level of serum adiponectin so that atherosclerosis occurs at last and the cerebral infarction may be induced.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2008年第4期286-288,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
脑梗塞
巨细胞病毒感染
动脉硬化
白细胞介素6
脂联素
brain infarction
cytomegalovirus infections
arteriosclerosis
interleukin-6
adiponectin
