摘要
目的:报道1例发生于颅内右顶叶的间叶性软骨肉瘤,并结合文献探讨其临床及组织病理学特点。方法:对1例发生于右顶叶的间叶性软骨肉瘤进行常规病理及免疫组化观察。结果:成年男性患者,左侧肢体乏力伴下肢间断性抽搐半年,头颅MRI示右顶叶占位。镜下可见肿瘤组织主要由弥漫性大小基本一致的小圆形瘤细胞及散在分布的小岛屿状的软骨细胞灶构成,核分裂像较少。免疫组化染色软骨区表达S-100(++),不表达CK(-)、EMA(-)、NF(-)、GFAP(-)、NSE(-)、CD34(-)。结论:原发于颅内的间叶性软骨肉瘤极为罕见,诊断时容易误诊,主要依赖于临床、影像学、病理学三方面的结合,并且需与少突胶质细胞瘤、血管外皮细胞瘤、滑膜肉瘤等相鉴别。
Objective：To report one case of mesenchymal chondrosarcoma occurring in fight parietal lobe and study its clinical and pathological features. Methods：One case of mesenchymal chondrosarcoma from right parietal lobe was investigated by histopathology and immunohistochemisty observation. Results：A male patient with a symptom of intermittent asthenia and convulsion in left limb for half a year , MRI of the skull showed space occupying lesion. Microscopically, the tumor tissue consisted of small and round tumor cells which were same in size and focal cartilage islands. Mitotic figure was rare. In immunohistochemistry, the focal cartilage islands were positive for S - 100, but negative for CK, EMA, NF, GFAP, NSE and CD34. Conclusion： Intracranial mesenchymal chondrosarcoma was rare. Its diagnosis mainly relied on the combination of clinic, imagology and histopathology, and it should be differentiated from oligoden - droglioma, haemangiopeficytoma and ＂synoviosarcoma.
出处
《现代肿瘤医学》
CAS
2008年第4期545-547,共3页
Journal of Modern Oncology
关键词
颅内
间叶性软骨肉瘤
临床病理
免疫组化
intracalvairum
mesenchymal chondrosarcoma
clinicopathology
immunohistochemistry
