摘要
本实验采用肝癌发生的动物模型，进行了缺铁饲料对ＤＥＮ诱发的大鼠肝癌前病变即呈γ－谷胺酰转换酶（ＧＧＴ）阳性灶的定量分析及ＤＮＡ氧化损伤即ＤＮＡ中８—羟基—２—脱氧鸟苷（８—ＯＨｄＧ）产生量的测定。结果表明：缺铁组呈ＧＧＴ阳性的病灶数显著减少，但灶的大小无改变；ＤＮＡ中８—ＯＨｄＧ产生显著降低，提示出：铁缺乏对癌前病变的增生有抑制作用，其机理可能与ＤＮＡ的氧化损伤的减少有关。
The inhibitory effects of iron deficiency diets on the development of putative preneoplastic,r-glutamyltransferase (GGT) positive hepatocyte focal lesions and 8-hydroxyldeoxyguanosine(8-OHdG) formation in DNA in rat liver initiated with diethylnitrosamine(DEN) were investigaed.Results are in iron deficient group,the number of GGT-positive foci and 8-OHdG formation in DNA were significantly decreased,but the size of foci were not changed.The results indicated that iron deficient diet have inhibitory effects on the development of GGT-positive foci.The mechanism may be related to decrease of DNA oxygenic damage,suggesting that iron deficiency play a role in development of preneoplastic lesions in the rat livers initiated with DEN.
出处
《癌变·畸变·突变》
CAS
CSCD
1997年第5期279-284,共6页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
肝癌
癌前病变
缺铁
动物实验
二乙基亚硝胺
Iron deficient diet
r-glutamyltranspeptidase(GGT)-positive foci
8-hydroxydeoxyguanosine(8-OHdG)
Inhibition
Animal experiment
