1Evans MJ, Kaufman MH. Establishment in culture of pluripotential from mouse embryos[J]. Nature, 1981,292 (5819) : 154 - 156.
2Martin G. Isolation of a pluripoten cell line from early mouse embryos cultured in medium conditioned by teratocarcinom stem cells [J ]. Proc. Natl. Acad. Sci. USA, 1981,78 (12) : 7634 - 7638.
3Zulewski H , Abraham EJ, Gerlach MU, et al. Multipotential Nestin positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes[J]. Diabetes,2001,50(3): 521 - 533.
4Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets[J]. Science,2001,292(5520) :1389 - 1394.
5Blyszczuk P, Czyz J, Kania G, et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin positive progenitor and insulin-producing cells[J]. Proc. Natl. Acad. Sci. USA,2003,100 : 998- 1003.
6Sharma A, Zangen DH, Reitz P, et al. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration[ J ]. Diabetes, 1999,48:507 -513.
7Kojima H, Nakamura T, Fujita Y, et al. Combined express of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin [ J ]. Diabetes,2002,51 : 1398 - 1408.
8TL Halvorsen, GM Beattie, AD Lopez, et al. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro[J ]. Endocrinology, 2000,166(1) :103 - 109.
4Evans MJ,Kaufman MH.Establishment in culture of pluripotential from mouse embryos[J].Nature,1981,292(5819):154-156.
5Martin G.Isolation of a pluripoten cell line from early mouse embryos cultured in medium conditioned by teratocarcinom stem cells[J].Proc Natl Acad Sci USA,1981,78(12):7634-7638.
6Thomson JA,Itskovitz-Eldor J,Shapiro SS,et al.Embryonic stem cell lines derived from human blastocysts[J].Science,1998,282(5391):1145-1147.
8Richards M,Fong CY,Chan WK,et al.Human feeders support prolonged undifferentiated growth of human inner cell masses and embryonic stem cells[J].Nat Biotechnol,2002,20(9):933-936.
9Dravid G,Ye Z,Hammond H,et al.Defining the role of Wnt/beta-catenin signaling in the survival,proliferation,and self-renewal of human embryonic stem cells[J].Stem Cells,2005,23(10):1489-1501.
