摘要
目的观察椎间盘源性腰痛的病理形态学特征,探讨其病理机制。方法选取20例椎间盘源性腰痛的椎间盘手术标本,常规HE染色,光学显微镜观察分析。结果镜下见椎间盘髓核面积减少,髓核中活性软骨细胞少,退变细胞多;纤维环增厚,从内层至外层纤维环可见不同程度的破裂,纤维环软骨细胞减少,软骨基质增多。结论椎间盘源性腰痛的主要致病机制可能是椎间盘形态结构的改变作用。
Objective To observe the pathomorphologic characteristic of discogenic low back pain which guide to study its pathological mechanism. Methods Twenty cases of confirmed discogenic low back pain were selected, hematoxylin and eosin-stained slides of intervertebral disc surgical specimens were reviewed. Results Surface area and activated chondrocytes decreased in the nucleus pulposus, where degenerated chondrocytes increased. Increased and variable rapture in fibrous ring of intervertebral disc was discovered from inside to outside layer, in which chondrocytes decreased and cartilage matrix increased. Conclusions The major pathogenesis of discogenic low back pain may be morphologic structural changes of lumbar intervertebral disc.
出处
《国际骨科学杂志》
2008年第2期131-132,共2页
International Journal of Orthopaedics
关键词
脊柱疾病
椎间盘源性腰痛
病理学
Spinal diseases
Discogenic low back pain
Pathology
