摘要
目的探讨阿卡波糖是否可以降低缺血性脑卒中合并葡萄糖耐量减低（IGT）患者再发脑卒中的风险。方法416例TIA或小型缺血性脑卒中患者发病1个月后行口服75g葡萄糖耐量试验，合并IGT患者119例，将其随机分为两组，60例用阿卡波糖干预（药物干预组），59例仪随访观察（随访观察组），另外再从未诊断为IGT的患者中随机选出70例患者作为对照组。三组均给予小剂量阿司匹林治疗（50mg／d），观察时间为3年。结果药物干预组再发脑卒中的发生率较随访观察组明显减低（13．33％比28．81％，P〈0．05），与对照组（12．86％）比较差异无统计学意义（P〉0．05）。结论阿卡波糖可以降低缺血性脑卒中合并IGT患者再发脑卒中的风险。
Objective To determine whether acarbose could decrease the risk of recurrent slroke in impaired glucose tolerance （IGT） patients wilh ischemic stroke. Methods Four hundred and sixteen patients with transient ischemic attack （TIA） or minor ischemic stroke were selected into this trial and parlici-paled 75g oral glucose tolerance test （OGTT） 1 month after I heir diagnosis and recovery of the disease. One hundred and nineteen IGT patients were randomly divided into two groups. Patients in pharmaceutical intervention group were treated with acarbose while those in the observation group were not. Seventy patients were selected randomly in those patients without IGT （control group）. All patients of the three groups were administered low dose aspirin. Results During 3 years follow-up, 8 patients （13.33%） experienced a stroke in pharmaceutical intervention group. The risk of recurrent stroke was decreased significantly compared with that in observation group （P 〈 0.05 ）, and there was no significant difference between pharma-ceutical intervention group and control group （P 〉 0.05）. Conclusion Acarbose can degrade the risk of recurrent stroke in IGT patients with ischemic stroke.
出处
《中国医师进修杂志（内科版）》
2008年第4期20-22,共3页
Chinese Journal of Postgraduates of Medicine
关键词
阿卡波糖
葡萄糖耐量试验
脑血管意外
复发
Acarbose
Glucose tolerance test
Cerebrovascular accident
Recurrence
