摘要
目的:提高对播散型组织胞浆菌病(PDH)的认识。方法:结合1例PDH患者的临床资料及文献复习,对本病病原学、流行病学、临床表现、诊断、鉴别诊断和治疗等方面进行分析。结果:患者以不规则发热、消瘦、全身淋巴结肿大为主要临床表现,组织病理学检查镜下找到组织胞浆菌孢子。氟康唑治疗有效。结论:PDH是由组织胞浆菌引起的累及全身单核巨噬细胞系统的深部真菌病,临床表现多样,确诊有赖于病原菌的检查。
Objective：To improve the clinical recognition of disseminated histoplasmosis（PDH）. Methods：We presented a case of PDH and reviewed the etiology, epidemiology, clinical manifestations, diagnosis,differential diagnosis and treatment of the disease. Results：A previously healthy 19-year-old man presented with systemic symptoms consisting of irregular fever, significant body weight loss and peripheral lymphadenopathy. Histoplasma capsulatum yeasts were detected in microscopic examination of biopsy material. The patient＇s clinical Status remained stable after fluconazole treatment. Conclusion： PDH is an important deep mycosiscaused by Histoplasma capsulatum and affects mainly the mononuclear-phagocytic system. This disease has variable clinical findings with only pulmonary or systemic involvement. The definitive diagnosis is achieved by direct diagnosis performed by micro and/or macroscopic observation of Histoplasma capsulatum.
出处
《中国误诊学杂志》
CAS
2008年第11期2533-2535,共3页
Chinese Journal of Misdiagnostics
