摘要
目的:探讨急性脑卒中患者甲状腺功能改变与情感变化相关性。方法:对62例急性脑卒中患者进行分组(单纯卒中组35例和卒中后抑郁组27例)收集两组入院d2、d7及d14两次空腹血清,采用化学发光法测定甲状腺功能,并与30例正常健康体检者(对照组)进行比较。结果:卒中后抑郁组较单纯卒中组比血清游离三碘甲状腺原氨酸(FT3)水平明显下降,而血清游离甲状腺素(FT4)水平显著增高,且卒中后抑郁组比卒中后无抑郁组的变化程度更显著;单纯卒中组血清促甲状腺素(TSH)水平比对照组显著增高,但卒中后抑郁组TSH水平升高不明显;而在入院d14,单纯卒中组FT3、FT4、TSH均恢复接近正常,与对照组比较无差异,而卒中后抑郁组FT3、FT4虽有恢复但不明显,与对照组比较无显著差异。结论:急性脑卒中患者甲状腺功能发生变化,而FT3、FT4及TSH水平变化与患者并发卒中后抑郁有关。
Objective： To investigate the relationship between the changes of thyroid function in patients after acute stroke and post - stroke depression. Method： 62 patients suffering from stroke were divided into two groups including patients without affective disorder （ 35 cases ） and patients with post -stroke depression group （ 27 cases）. Thyroid function （ FT3, FT4,TSH） were assayed by chemolumin inescence method on the second day ,the 7th day,and the 14th day after hospital, and compared with the normal control group （30 cases ）. Result： The level of FT3 were significantly decreased both the patients without affective disorder and patients with post - stroke group compared with the normal control group, while the level of FT4 increased obviously compared with the normal control. In addition, the changes of the levels of FT3 and FT4 in patients with post - stroke group was more obviouse than those in patients without affective disorder. TSH was greatly increased in the patients without affective disorder,while no obviousely in patients with post- stroke depression. On the 14th day after hospital,the levels of FT3 ,FT4 were almost within the normal range in the patients without affective disorder, but the levels of FT3 , FT4 in patients with post - stroke depression had no greatly withdraw. Conclusion： The thyroid function changed after acute stroke, and the change of the levels of FT3 , FT4 and TSH related with the post- stroke depression after stroke.
出处
《河北医学》
CAS
2008年第2期153-156,共4页
Hebei Medicine
关键词
脑卒中
卒中后抑郁
甲状腺功能
神经分泌学
Acute stroke
Post - stroke depression
Thyroid function
Neuroendocrinology
