摘要
本文目的旨在探讨凝血酶原片段F1+2的检测及其在高凝、低凝中的变化。40例血栓形成性疾病（下肢深部静脉血栓24例，急性心肌梗塞16例）及50例口服抗凝治疗患者用于该研究，并以40例正常健康人作对照。结果显示：F1+2正常值0．40±0.23nmol／L（范围0．11～1．19nmol/L），下肢深部静脉血栓F1＋2值2．99±1．47nmol／L（范围1．01～6．03nmol／L），急性心肌梗塞F1+2值3．77±2.38nmol／L（范围1.13～7．81nmol／L），均非常明显高于正常值（P<0．001）。口服抗凝治疗患者F1+2值0．24±0．22nmol／L（范围0．1～0．75nmol／L），显著低于正常值（P<0．05），提示两种血栓形成性疾病及口服抗凝治疗分别表现为高凝及低凝倾向。因此，F1＋2的检测可作为高凝状态及对抗凝治疗进行监测的分子标志。
The purpose of this study was to investigate thedetermination of prothrombin fragment 1 + 2 (f1 + 2 )and its changes under hypercoagulable and hypocoag-ulable states. 40 consecutive patients with throm-boembolic events (24 deep venous thrombosis, 16 a-cute myocardial infarction ) and 50 patients who re-ceived oral anticoagulant therapy were utilized forthis study,and 40 healthy indlviduals served as nor-mal control. The results show that normal controlvalues of F1 +2 in healthy individuals were 0. 40+0.23 nmol/L (ranging from 0. 11 ~ 1. 19 nmol/l, ). thevalues of F1 +2 in deep venous thromhosis and acutemyocardial infarction were 2. 99+ 1. 47nmol/L, (rang-ing from 1. 01 ~6. 03 nmol/L,)and 3. 77+ 2. 38 nmol/L(ranging from 1. 13 + 7. 81 nmol/L ) respectively.Very significantly increased F1 + 2 were measured inboth patients with deep venous thrombosis and acutemyocardial infraction in comparison with normal val-ues(P< 0. 001 ), Mean plasma levels of F1 + 2 weresignificantly lower in the oral anticoagulant patients(0. 24 + 0. 22 nmol/L ranging from 0. 05 ~ 0. 75nmol/L) as compared with the health controls (P<0. 05). These findings implemented that both patientswith thrombotic disorders and oral anticoagulanttherapy presented respectively hypercoagulsble orhypocoagulable. Thus, measurement of F1 + 2 levelsshould serev as an molecular marker of hypercoagula-ble state as well as in monitoring anticoagulant thera-py
出处
《贵州医药》
CAS
1997年第5期257-259,共3页
Guizhou Medical Journal
关键词
凝血酶原片段
深部脉血栓
心肌梗塞
prothrombin fragment F1+2 deep venous thrombosis acute myocardiac infarction anticoagulant therapy oral
