摘要
采用放射免疫法观察血液透析患者血浆内皮素－１（ＥＴ－１），降钙素基因相关肽（ｃＧＲＰ）浓度改变及其对血压的影响。结果表明：①血液透析患者血浆ＥＴ－１，ｃＧＲＰ浓度较正常人及慢性肾疾患肾功能正常者高。②不同透析时间内血浆ＥＴ－１、ｃＧＲＰ浓度呈动态变化。③血浆ＥＴ－１与血压呈正相关；血浆ｃＧＲＰ与血压呈负相关。提示：血浆ＥＴ－１和ｃＧＲＰ均可能是引起血透患者血压变化的主要因素。
Plasma endothelin 1(ET 1) and calcitonin gene related peptides (cGRP) were studied by immunoradiological method in 60 hemodialysis (HD) patients. The results showed that: ① Plasma level of ET 1 and cGRP were increased in the HD patients. ② Plasma level of ET 1 and cGRP varied in different times of HD. ③ A significantly positive relation between plasma ET 1 and blood pressure (BP) existed in the HD patients, while a significantly negative relation between plasma cGRP and BP existed in the HD patients. The results suggest that ET 1 and cGRP are major factors which lead to BP changes in HD patients.
出处
《湖南医科大学学报》
CSCD
1997年第4期335-337,共3页
Bulletin of Hunan Medical University
