摘要
为了解血液流变学改变在急性胰腺炎发展中的作用，作者采用急性胰腺炎大鼠模型，观察了用右旋糖酐致血液流变学变化后的急性胰腺炎的胰组织病理改变。９６只４月龄Ｗｉｓｔａｒ大鼠在手术结扎胰管后随机分为三组。Ⅰ组静脉推注促胰泌素；Ⅱ组静脉推注１１００００分子量右旋糖酐；Ⅲ组则顺序静脉推注促胰泌素和１１００００分子量右旋糖酐。另１０只大鼠做单纯开腹对照为Ⅳ组。结果显示Ⅰ组的大鼠发生急性水肿性胰腺炎，Ⅱ组的大鼠尽管有明显的血液流变学改变，但仅见类似单纯结扎胰管后发生的胰组织轻度水肿改变；Ⅲ组则发生急性出血坏死性胰腺炎，并观察到胰腺病变由初始的水肿渐进发展成出血坏死的病变过程，提示血液流变学异常不是急性胰腺炎致病因素。但在疾病发生后对胰腺病变的损害加重起促进作用，尤其表现在水肿型转为出血坏死型的过程中。
This study sought to determine the effect of the haemorrheological changes on the pathological damage to pancreas in acute pancreatitis. 96 Wistar rats, four months old, were allocated into three groups: group Ⅰ ( n =32) received surgery for pancreatic duct obstruction (PDO) with secretin stimulation; group Ⅱ ( n =32) for PDO with high molecular dextran (DX 110 ) injection intravenously, and group Ⅲ ( n =32) for PDO with secretin stimulation and DX 110 injection intravenously. Ten other rats were used as controls (group Ⅳ) for laparotomy alone. The results showed that PDO with hypersecretion could induced edematous pancreastitis and PDO with DX 110 injection induced only very lightly oedema in the pancreas which was similar to the result of PDO alone, although the haemorrheological changes were obvious in these rats. PDO with hypersecretion and DX 110 injection induced acute necrotic pancreatitis, and the pathological lesion in the pancrease which changed gradually from edematous to necrotic could be observed. This result suggests that haemorrheological change may not be a causative factor of the acute necrotic pancreatitis, but it probably could exacerbate the damage to pancreas in acute pancreatitis and play an important role in the transformation from edematous to necrotic pancreatitis.
出处
《华西医科大学学报》
CSCD
1997年第2期218-221,共4页
Journal of West China University of Medical Sciences
关键词
胰腺炎
血液流变学
大鼠
Acute pancreatitis Haemorrheological changes Rats
