摘要
具光学活性的内型－三环〔５，２，１，０２，６〕癸－８－烯－３，５－二醇－５－乙酸酯是合成光学活性天然产物的很有用的手性合成子。采用正交试验优选出目标化合物最佳合成条件后，按作者设计的条件进行实验，获得了（＋）内型－三环〔５，２，１，０２，６〕癸－８－烯－３，５－二醇－５－乙酸酯。其（＋）对映体过量百分率（％ｅ．ｅ）＞９８．３％，产率８１％。提示本文报道的优化条件对该酶促反应是适合的。
Optically active endo tricyclo 5,2,1,0 2,6 deca 8 en 3,5 diol 5 acetate is a very useful chiral synthon for the synthesis of optically active natural products.In this paper,the optimal conditions for the synthesis of this compound was established by orthogonality test.Under these conditions,the chemical percentage yield of acetylation of (+[HT5”〗) endo tricyclo 5,2,1,0 2,6 deca 8 en 3,5 diol 5 acetate and its % e.e can reach up to 81% and 98.3% respectively.The optimazation of the conditions is efficient for the reaction of enzyme catalyzed esterification.
出处
《华西医科大学学报》
CSCD
1997年第2期167-169,共3页
Journal of West China University of Medical Sciences
关键词
酶促反应
有机合成
反应条件
正交实验
均匀设计
Endo tricyclo 5,2,1,0 2,6 deca 4,8 dien 3 olacetate (+)Endo tricyclo 5,2,1,0 2,6 deca 8 en 3,5 diol 5 acetate Orthogonality test Enzyme catalyzed acetylation Uniform design
