摘要
目的探讨非小细胞肺癌组织血管内皮生长因子C(VEGF-C)及VEGF受体3(VEGFR-3)表达对淋巴管生成和淋巴转移意义。方法用免疫组化方法检测62例非小细胞肺癌组织VEGF-C和VEGFR-3的表达情况。结果非小细胞肺癌组织中,VEGF-C阳性表达率为77.4%,有淋巴结转移组VEGF-C阳性表达率显著高于无淋巴结转移组(χ2=7.33,P<0.05)。VEGFR-3阳性表达率为74.4%,淋巴结转移组VEGFR-3阳性微淋巴管数量明显多于无淋巴结转移组(t=11.18,P<0.05)。VEGF-C表达强度越高,VEGFR-3阳性微淋巴管数量越多,二者呈正相关(r=0.912,P<0.05)。结论非小细胞肺癌组织中VEGF-C的表达与VEGFR-3阳性微淋巴管数量和淋巴结转移有关。
Objective To investigate the significance of VEGF-C and VEGFR-3 expression on lymphangiogensis and me tastasls in non small cell luug cancer. Methods The expression of VEGF-C and VEGFR-3 were detected by immunohistochemistry in 62 patients with non-small cell lung cancer. Results Of the 62, the positive rate of VEGF-C and VEGFR-3 was 77.40/00 and 74. 4%, respectively. The positive VEGF-C in the lymph-node metastasis group was significantly higher than that of non-melastasis （χ2 = 7.33, P〈0.05）. The number of VEGFR 3 positive lymphatic vessels was higher than that of the non-metastasis （t= 11.18,P〈0.05）. The more strength the expression of VEGF-C was, the more number of VEGFR-3 positive lymphatic vessels would be （r=0. 912, P〈0.05）. Conclusion The expression of VEGF-C in NSLC is related with VEGFR-3 positive lymphatic vessels and lymph node metastasis.
出处
《青岛大学医学院学报》
CAS
2008年第1期6-7,10,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
癌
非小细胞肺
血管内皮生长因子C
血管内皮生长因子受体3
淋巴管生成
淋巴转移
Carcinoma. non small cell lung
Vascular endothelial growth factor C
Vascular endothelial growth factor recptor-3
Lymphangiogensis
Lymphatic metastasis
