摘要
目的制备水飞蓟宾脂质体并观察其稳定性。方法采用薄膜法制备水飞蓟宾脂质体,并对其粒径、表面电位、包封率等稳定性指标进行观察。结果所得脂质体具有粒径小而均匀的特点;在室温条件下密封放置9 d及4℃下保存10个月,其外观性状、粒径、表面电位、包封率等无显著性改变。结论脂质体技术能够成功地包裹水飞蓟宾,在短期内能保证良好的稳定性。
Objective To prepare silybin liposomes and investigate its stability.Methods Silybin liposomes were prepared by thinfilm dispersion technology. The stability indices, such as grain size, surface potential and encapsulation efficiency, were investigated. Results The prepared liposomes were characterized by small and steady grain size. No obvious changes were found in appearance, grain size, surface potential, and encapsulation efficiency of liposomes in airtight storage for 9 days or stored at 4℃ for 10 months. Conclusion The technology of li posome preparation can encapsulate silybin , which maintain good stability in a short period of time.
出处
《武警医学》
CAS
2008年第3期230-232,共3页
Medical Journal of the Chinese People's Armed Police Force
关键词
水飞蓟宾
脂质体
薄膜法
制备
稳定性
Silybin Liposomes Thin- film dispersion Preparation Stability
