摘要
随着生物技术的发展,研究人员构建出了大量具有特定功能的基因工程微生物,这些基因工程微生物在实际应用时常受到限制,因为它们释放到环境中有可能带来新的污染。为了减少或消除其对环境的潜在危害,有必要采取措施对这些基因工程微生物进行监测和安全控制。通常要求这类基因工程微生物带有便于监测的检测标记以及能进行自消亡的主动生物防御体系。对基因工程微生物的检测标记以及主动生物防御体系的研究现状进行了综述。
With the development of biological technology, many genetically engineered microorganisms （GEMs） for special purposes have been constructed and developed, but their practical applications in the field are still limited because GEMs may cause new environmental contaminations. To minimize the potential risks, the organisms released to environment need to be monitored and restricted for their distribution. In the laboratory conditions, the GEMs can be wiped off when required using some new biological technologies. The recent progress of research on the monitoring methods and active biological containment system for GEMs were reviewed in this paper.
出处
《生物工程学报》
CAS
CSCD
北大核心
2008年第3期355-362,共8页
Chinese Journal of Biotechnology
基金
中国科学院知识创新工程领域前沿项目(No.KSCX-IOZ-0701)
国家863项目(No.2002AA601160)~~
关键词
基因工程微生物
环境监测
主动生物防御体系
自杀基因
genetically engineered microorganisms, environmental monitoring, active biological containment system, suicide gene
