摘要
目的与方法 1994年上海南市区新生儿与学龄前儿童普种乙肝疫苗后8年乙肝感染和免疫水平进行血清学调查。结果与结论与十年前相比,1～8岁儿童 HBsAg 平均携带率从既往9.21%下降为0,41%;9～14岁儿童的携带率从12.8%下降到2%以下,而15岁以上 HBsAg 则与1984年本底调查结果一致,仍保持在10%以上,说明乙肝疫苗远期效果很好,实施新生儿普种,可在一代人期间使人群 HBsAg 携带率降到1%以下.学龄前接种也可得到显著的免疫效果。随着乙肝疫苗在人群中的大规模应用,人群免疫水平大大提高,因接种年限不等,1～12岁人群抗-HBs 阳性率在50%与90%之间.
Objective To investigate long-tern effect of universal hepatitis B vaccination on control of HBV infection. Methods Universal hepatitis B vaccination in newborns and preschool children have been implemented in Nanshi district,Shanghai since 1986.In 1994 three serologic markers(HBsAg,anti-HBs and anti-HBc)among 1-16 year and 20～29 year old people were examined in this district.Results In children youger than 15 years,HBsAg carrier rate was significantly reduced.In the age group of 1 to 8,the rates of HBsAg positive were all below 1% with an average of 0.41%.The carrier rate was 1～2% in 9～12 years old and 3.08% in 13～14 years age group respectively. These results were consistent with the results of longitudinal cohort studies.Conclusion the effectiveness of HB vaccine is long-lasting and universal infant hepatits B vaccination is the most promising measure for reduction of HBsAg carrier rate.
出处
《中华肝脏病杂志》
CAS
CSCD
1997年第1期39-41,共3页
Chinese Journal of Hepatology
