摘要
目的:研究氨氯地平与地高辛合用对心衰大鼠体内地高辛的药动学影响。方法:采用腹主动脉狭窄方法制作大鼠心衰模型,实验分地高辛单用组和地高辛与氨氯地平合用组,采用荧光偏振免疫法检测血浆中地高辛的浓度,药-时数据经DAS ver1.0软件处理,确定单用组与合用组的药动学参数。结果:合用氨氯地平后,地高辛的达峰时间由0.67h推迟为1.00h,AUC0-24由(15.2±6.0)μg.L-1.h减少为(13.6±4.1)μg.L-1.h,经配对t检验,2组间主要药动学参数T1/2α,T1/2β,AUC0-24,CL/F,Cmax均无显著性差异(P>0.05)。结论:氨氯地平对心衰大鼠体内地高辛的药动学过程无影响。
OBJECTIVE To study the effect of amlodipine on the pharmacokinetics of digoxin in rats with heart failure. METHODS The model of heart failure was made by applying abdominal artery constriction. Wistar rats were randomly divided into digoxin group and digoxin combined with amlodipine group. Concentration of digoxin in plasma was determined by Fluorescence Polarization Immunoassay. The pharmacokinetic parameters were calculated by DAS vet 1.0. RESULTS Compared with digoxin group, the Tmax of digoxin combined with amlodipine group was changed from 0. 67 h to 1.00 h, the AUC0-24was decreased from （ 15.24 ± 6. 05 ） ng · L^-1 · h to （ 13.62 ± 4. 08 ） ng · L^-1 · h. With paired T-test, t1/2α, t1/2β, AUC0-24 , CL/F, Cmax were no obvious different between two groups. CONCLUSION Amlodipine had no influence on pharmacokinetic parameters of digoxin in rats with heart failure.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第5期338-340,共3页
Chinese Journal of Hospital Pharmacy
关键词
氨氯地平
地高辛
心衰大鼠
药动学
amlodipine
digoxin
rats with heart failure
pharmacokinetic
