摘要
目的了解黄芪煎液对小肠血流量和运动的影响．方法采用不同浓度（１０％，３０％及５０％）的黄芪煎液置入１０条健康杂交狗的空肠中，运用电磁血流计和压力传感器观测其对小肠血流量和运动的影响．并以生理盐水作为对照进行了对比观测．结果将黄芪煎液置于在体狗小肠后，小肠血流量（ｍｌ·ｍｉｎ－１·１００ｇ－１）增加，高达５４８５±１１８６～７３５５±１２４０，与生理盐水组４２５６±９３４～４３１５±１０２３相比较差异有显著性（Ｐ＜００５）或高度显著性（Ｐ＜００１）；小肠平滑肌张力（ｋＰａ）增强，高达０７０±０２７～０９５±０３９，与生理盐水组０４４±０２１～０５１±０２２相比较差异有显著性（Ｐ＜００５）；小肠蠕动振幅（ｍｖ）增高，高达１０５３±２３７～１２０４±３３７，与生理盐水组６５２±２３１～６４４±２１８相比较，差异有显著性（Ｐ＜００５）．结论黄芪具有促进小肠消化功能的作用，不同浓度的黄芪煎液对小肠的作用存在着一定的差异．
AIM To study effect of Astragalus membranaceus on intestinal blood flow and motility. METHODS Different concentrations of Astragalus membranaceus (10%, 30% and 50%) were placed into intestinal lumen of 10 healthy mongrel dogs to observe their effects on intestinal blood flow and motility using electromagnetic flowmeter and pressure transducer, and compared with normal saline. RESULTS Astragalus membranaceus significantly or very significantly increased intestinal blood flow (ml·min -1 ·100 -1 ) to 54 85±11 86～73 55±12 40, compared with 42 56±9 34～43 15±10 23 of normal saline ( P <0 05 or <0 01), significantly enhanced intestinal muscular tension (kPa) to 0 70±0 27～0 95±0 39, compared with 0 44±0 21～0 51±0 22 of normal saline ( P <0 05), and significantly raised intestinal motility amplitude (mv) to 10 53±2 37～12 04±3 37, compared with 6 25±2 31～6 44±2 18 of normal saline ( P <0 05). The effect varied among different concentrations of Astragalus membranaceus on digestive function of intestine. CONCLUSION Astragalus membranaceus can improve the function of intestinal digestion.
关键词
黄芪
药理学
小肠
血流量
动物实验
胃肠活动
Astragalus membranaceus /pharmacology
intestine, small/drug effects
intestine, small/blood supply
gastrointestinal motility/drug effects
